REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1516419
This article is part of the Research TopicAntibody-drug Conjugates in Solid and Hematologic MalignanciesView all 4 articles
Antibody-Drug Conjugates in Cancer Therapy: Applications and Future Advances
Provisionally accepted
- University of South China, Hengyang, China
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Antibody-Drug Conjugates (ADCs) represent an emerging cancer therapeutic strategy and are becoming increasingly significant in the field of public health. With the evolution of precision oncology, the potential applications of ADCs are being realized more broadly.This review provides an overview of the fundamental molecular design of ADCs, examining how each component-antibody, linker, payload, and coupling chemistry-affects the physicochemical and biological properties of the final product. The paper also discusses novel ADC designs that are in preclinical and early clinical development stages as next-generation cancer therapies. These include bispecific ADCs, Probody-drug conjugate, immunostimulatory ADCs (ISACs), Degrader-Antibody Conjugates (DACs), and Dual-Payload ADCs. Their applications and potential future advancements in cancer therapy are also explored.
Keywords: Antibody-drug conjugates, ADCS, Linker, Probody-drug conjugate, Dual-Payload ADCs
Received: 24 Oct 2024; Accepted: 29 Apr 2025.
Copyright: © 2025 L, T, Z, Y, L, L, D, Q, L and Zuo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
R L, University of South China, Hengyang, China
GY T, University of South China, Hengyang, China
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