ORIGINAL RESEARCH article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1538219
This article is part of the Research TopicMolecular Characterisation of Autoimmune DiseasesView all 6 articles
N-glycosylation patterns of plasma immunoglobulin G in antisynthetase syndrome disease
Provisionally accepted
Jing Zhao1,2
Yanhong LI1,2
Yingying Li1
Tong Wu1,2
Yinlan Wu1,2
Chunyu Tan1,2
Lu Cheng1
Deying Huang1,2
Yong Zhang1*
Yi Liu1,2*- 1Sichuan University, Chengdu, China
- 2Rheumatology and Immunology Department of Huaxi Hospital, chengdu, China
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Anti-synthetase syndrome (ASS) is a subtype of idiopathic inflammatory myopathy (IIM) characterized by characteristic rash, myositis, and interstitial lung disease (ILD). The etiology of ASS is unknown, and patients have poor quality of life and are prone to pulmonary infection. Recent studies have elucidated the potential role of abnormal glycosylation of immunoglobulin G (IgG) in the occurrence and development of autoimmune diseases. However, the pattern of patient-specific IgG N-glycosylation in ASS has not been fully elucidated. In this study, the GlycoQuant method was used to quantify the intact N-glycopeptides of IgG from 30 ASS patients and 30 healthy controls (HCs). Thirteen differentially expressed intact N-glycopeptides were identified (p<0.05). Notably, we observed increased fucosylation (p<0.0001) and decreased N-acetylneuraminic acid (p<0.05) in ASS patients. In addition, associations between specific glycosylation and lung function parameters were observed. Our study revealed the IgG glycosylation profile in ASS patients and provided a valuable reference for further investigation of its potential diagnostic and prognostic applications.
Keywords: autoimmune disease, Anti-synthetase syndrome (ASS), N-glycosylation, Intact N-glycopeptide, Immunoglobulin g (IgG)
Received: 02 Dec 2024; Accepted: 03 Jun 2025.
Copyright: © 2025 Zhao, LI, Li, Wu, Wu, Tan, Cheng, Huang, Zhang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yong Zhang, Sichuan University, Chengdu, China
Yi Liu, Sichuan University, Chengdu, China
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