CASE REPORT article

Front. Immunol.

Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1549363

This article is part of the Research TopicCase Reports in Autoimmune and Autoinflammatory Disorders: Volume IIView all 6 articles

Pediatric age onset CNTN1 antibody-associated neuropathy with nephropathy and literature review

Provisionally accepted
Ceyda Bayraktar EltutanCeyda Bayraktar Eltutan1*Simon RinaldiSimon Rinaldi2Atay VuralAtay Vural3Bagdagul AksuBagdagul Aksu1Hulya Maras GencHulya Maras Genc1Edibe YildizEdibe Yildiz1
  • 1Faculty of Medicine, Istanbul University, Istanbul, Türkiye
  • 2Nuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Oxford, England, United Kingdom
  • 3Research Center for Translational Medicine, Koç University, Sarıyer, Istanbul, Türkiye

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We present a 12-year-old boy with acute onset sensorimotor neuropathy and membranous glomerulonephritis associated with contactin-1 antibodies. This prompted us to explore the clinical characteristics of this condition and assess whether its presentation differs between pediatric and adult patients. A comprehensive search was conducted across multiple online databases, including PubMed and EMBASE, using MeSH terms such as “chronic inflammatory demyelinating polyradiculopathy”, “acute inflammatory demyelinating polyradiculopathy “, “CIDP”, “Guillain Barre syndrome”, “proteinuria”, “nephrotic syndrome”, “nephropathy”, “renal disease”, “glomerulonephritis”, “membranous nephropathy”, “autoimmune nodopathies”, and “membranous glomerulonephritis”. We reviewed publications up to October 2024 and identified 39 patients with anti-contactin associated CIDP (chronic inflammatory demyelinating polyradiculopathy) with membranous glomerulonephritis (MGN), including our case. This rare coexistence typically occurs at advanced ages, with only two pediatric cases. Clinical features were similar regardless of age at onset. We compared the onset, symptoms, progression, renal histopathology, and treatment responses between pediatric and adult patients.

Keywords: chronic inflammatory demyelinating polyradiculopathy, Membranous glomerulonephritis, Autoimmune nodopathy, anti contactin antibody, case report

Received: 21 Dec 2024; Accepted: 28 May 2025.

Copyright: © 2025 Bayraktar Eltutan, Rinaldi, Vural, Aksu, Maras Genc and Yildiz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Ceyda Bayraktar Eltutan, Faculty of Medicine, Istanbul University, Istanbul, Türkiye

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