REVIEW article

Front. Immunol.

Sec. Inflammation

Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1550839

This article is part of the Research TopicInnovative Immunoregulation Strategies in the Chronic Inflammation-Based DiseasesView all 4 articles

Novel Insights into the Crosstalk between Non-coding RNA and Apoptosis in Rheumatoid Arthritis: Diagnostic Functions and Therapeutic Applications

Provisionally accepted
  • Anhui University of Chinese Medicine, Hefei, China

The final, formatted version of the article will be published soon.

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder and a leading cause of disability worldwide, significantly impairing patients' quality of life.As current therapeutic options remain limited, there is an urgent need for novel strategies, including the use of medicinal plants, to delay the development and progression of RA. Acute inflammation in RA is often accompanied by impaired apoptosis, which contributes to disease pathogenesis. With advances in high-throughput sequencing technologies, an increasing number of noncoding RNAs (ncRNAs) have been identified and extensively studied for their roles in both physiological and pathological processes. Dysregulation of these ncRNAs-particularly long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs)-has been implicated in various disorders, including RA. Given the well-established association between apoptosis and ncRNA expression in RA, a comprehensive understanding of their intricate interplay is essential. In this study, we systematically explore the complex interactions between lncRNAs and circRNAs in regulating apoptosis during the pathogenesis of RA. Additionally, we highlight emerging evidence suggesting that ncRNA-mediated modulation of apoptosis can be achieved through herbal medicines, offering promising therapeutic avenues for RA treatment.

Keywords: ncRNAs, Rheumatoid arthritis, Apoptosis, Therapeutic applications, TCM

Received: 24 Dec 2024; Accepted: 28 Apr 2025.

Copyright: © 2025 Wen, Liu, Wan and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Jian Liu, Anhui University of Chinese Medicine, Hefei, China

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