ORIGINAL RESEARCH article
Front. Immunol.
Sec. Systems Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1561477
This article is part of the Research TopicMicrobiome and Hematological Malignancies: Exploring the ConnectionView all articles
Hematopoietic effects of Fufang E'jiao Jiang revealed by microbiome, metabolome and transcriptome analyses: a multi-omics strategy
Provisionally accepted
- 1Shanghai University of Traditional Chinese Medicine, Shanghai, Shanghai Municipality, China
- 2Kunming University of Science and Technology, Kunming, Yunnan Province, China
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Fufang E'jiao Jiang has been extensively utilized to replenish qi and nourish blood as the homology of medicine and food. This study aimed to examine the anti-anemia mechanism of FEJ in relation to the microbiome, metabolome and transcriptome. FEJ markedly alleviated the anemia symptoms caused by cyclophosphamide and acetylphenylhydrazine induction. FEJ improved the gut microbiome imbalance by inhibiting the proliferation of harmful bacteria Turicibacter, Akkermansia and Tuzzerella. Fecal metabolomic data showed that FEJ regulated metabolic disorders in anemia mice and was probably associated with L-leucine, L-proline, glycine, phenylalanine, propanoic acid and butanoic acid. Transcriptome analysis indicated the amelioration of anemia was predominantly associated with the hematopoietic cell lineage, osteoclast formation and B cell receptor signaling pathway. According to Spearman's correlation analysis, there was a strong link between gut microbiota and hematopoietic index, metabolites and genes. Our study supports the application of FEJ in anemia treatment.
Keywords: Fufang E'jiao Jiang, Anemia, microbiome, Metabolome, Transcriptome FEJ improved gut microbiome dysbiosis by markedly
Received: 21 Jan 2025; Accepted: 22 May 2025.
Copyright: © 2025 Mo, He, Shi, Ning, Zhou, Cui, Cui and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ting Zhang, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, Shanghai Municipality, China
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