SYSTEMATIC REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1563967
This article is part of the Research TopicCurrent Perspectives in the Diagnosis of Parathyroid Disease - Volume IIView all 4 articles
Unravelling the link between chronic inflammation and primary hyperparathyroidism: a systematic review
Provisionally accepted
- 1University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania
- 2County Emergency Hospital Cluj-Napoca, Cluj-Napoca, Cluj, Romania
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Introduction: Primary hyperparathyroidism (PHPT) is a multisystemic endocrine disorder characterized by an incompletely understood pathogenesis, a complex clinical picture and various complications. Chronic inflammation represents a state that can affect the normal function of cells and cause tissue damage, therefore increasing the risk of certain diseases, including cancer, metabolic, cardiovascular or neurodegenerative disorders.Aim: Reviewing existing data on markers of inflammation in patients with PHPT, with potential implications in understanding the pathogenesis of PHPT, stratifying the risk for complications and providing new diagnostic biomarkers and a personalized therapeutic approach, especially in patients who cannot be operated on.Methods: A systematic review was conducted by searching in four electronic databases (PubMed, Embase, Web of Science and Scopus) and summarizing data from studies that evaluated inflammatory markers in patients with PHPT.The review included a total of 28 articles, encompassing data from 1572 patients diagnosed with PHPT. Various markers associated with chronic inflammation, including High sensitivity C-Reactive Protein (CRP), Tumor Necrosis Factor-α, Interleukin (IL)-6, and fibrinogen, were found to be elevated in PHPT patients. White blood count (WBC) values were similar in patients and controls in most studies, while for some markers derived from the full blood count significant differences were found between these groups. Correlations between PTH levels and several biomarkers, including IL-6, CRP and WBC, were also identified. Data on the impact of parathyroidectomy on inflammation parameters were conflicting.The findings from this systematic review suggest an association between chronic inflammation and primary hyperparathyroidism, underscoring the potential role of inflammation as a mediator of PHPT-related complications. Targeting inflammatory pathways may offer novel therapeutic strategies for mitigating systemic effects of PHPT and improving patient outcomes.
Keywords: chronic inflammation, Inflammatory biomarkers, primary hyperparathyroidism, Bone Resorption, cardiovascular disease
Received: 20 Jan 2025; Accepted: 14 May 2025.
Copyright: © 2025 GHEORGHE-MILEA, STANOIU-PINZARIU and GEORGESCU. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: OANA STANOIU-PINZARIU, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania
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