REVIEW article
Front. Immunol.
Sec. Molecular Innate Immunity
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1570128
This article is part of the Research TopicThe role of epigenetics in macrophage activation during the process of lung diseasesView all 3 articles
Roles of microRNAs in acute lung injury and acute respiratory distress syndrome: mechanisms and clinical potential
Provisionally accepted
- 1Taizhou University, Taizhou, China
- 2Jiaxing University, Jiaxing, Zhejiang, China
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Acute lung injury (ALI) is characterized by a systemic and excessive inflammatory response triggered by various direct or indirect pathogenic factors, resulting in increased permeability of the alveolar-capillary membrane and the accumulation of fluid in the alveolar and interstitial spaces. Clinical symptoms include reduced lung compliance, respiratory distress, and severe hypoxemia that is difficult to manage. Acute respiratory distress syndrome (ARDS) represents a more severe form of ALI. The incidence of ALI/ARDS among critically ill patients is approximately 10.4%, with a mortality rate as high as 45%. MicroRNA (miRNA) is a small, non-coding RNA molecule approximately 22 nucleotides in length, which plays diverse roles in cellular functions and exerts a significant regulatory influence on disease progression. Research related to miRNAs, particularly in the context of ALI/ARDS, has increased in recent years due to its crucial involvement in the disease process. This article elucidates the molecular mechanisms of miRNA and outlines the current research advancements in ALI/ARDS, offering novel insights into the pathogenesis and potential clinical applications of this condition.
Keywords: Acute Lung Injury, ARDS, microRNA, Mechanism, Pathogenesis
Received: 03 Feb 2025; Accepted: 08 Sep 2025.
Copyright: © 2025 Wang, Lai, Litong and Xue. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yi Xue, Taizhou University, Taizhou, China
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