ORIGINAL RESEARCH article

Front. Immunol.

Sec. NK and Innate Lymphoid Cell Biology

Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1571085

Single Cell Atlas of Canine Natural Killer (NK) Cells Identifies Distinct Circulating and Tissue

Provisionally accepted
Aryana M RazmaraAryana M Razmara1Marshall LammersMarshall Lammers1Sean J. JudgeSean J. Judge1William MurphyWilliam Murphy1Cameron GaskillCameron Gaskill1William CulpWilliam Culp2Alicia A GingrichAlicia A Gingrich1Zachary Scott MorrisZachary Scott Morris3Robert RebhunRobert Rebhun2C Titus BrownC Titus Brown2David M VailDavid M Vail4Michael Sean KentMichael Sean Kent2Robert J. CanterRobert J. Canter1*
  • 1School of Medicine, University of California, Davis, Sacramento, California, United States
  • 2School of Veterinary Medicine, University of California, Davis, Davis, California, United States
  • 3School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States
  • 4School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States

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with funding from the NCI P30 CA093373 (Cancer Center), and S10 RR 026825 (Fortessa Cytometer) grants, with technical assistance from Ms. Bridget McLaughlin and Mr. Jonathan Van Dyke. Additional generous support was provided by Shingle Springs Subaru gift funds. Laboratory Medicine. Maria Hernandez assisted in obtaining human placenta and Dr. Julia Leese assisted in obtaining canine placentas. Also special thanks to Dr. David T. Cooke and Dr. Sophoclis Alexopoulos from the UCD Department of Surgery for assistance with human lung and liver tissue procurement. Figure schemas were created with BioRender.com.

Keywords: canine (dog), Comparative, NK cell, single cell RNA sequencing (scRNAseq), Transcriptomics, tissue resident

Received: 04 Feb 2025; Accepted: 22 Apr 2025.

Copyright: © 2025 Razmara, Lammers, Judge, Murphy, Gaskill, Culp, Gingrich, Morris, Rebhun, Brown, Vail, Kent and Canter. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Robert J. Canter, School of Medicine, University of California, Davis, Sacramento, 95817, California, United States

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material