ORIGINAL RESEARCH article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1574113
This article is part of the Research TopicBioinformatics and Systems Biology Strategies in Disease Management with a Special Emphasis on Cancer, Alzheimer's Disease and AgingView all 5 articles
Immunological Biomarkers and Gene Signatures Predictive of Radiotherapy Resistance in Non-Small Cell Lung Cancer
Provisionally accepted
- 1The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, China
- 2Department of Radiotherapy，The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical Universi, Huai’an, China
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1.Identified 103 genes enriched in NSCLC radiotherapy resistance pathways. Using machine learning, pinpointed four key genes (TGFBI, FAS, PTK6, FA2H), with TGFBI highly correlated with prognosis.2.Found significant immune cell infiltration differences between high-and low-risk NSCLC patients, hinting at new therapeutic strategies involving macrophage polarization and B cell activation.3.Developed a prognostic model with high diagnostic accuracy based on identified genes, advancing understanding of radiotherapy resistance mechanisms and potentially improving patient outcomes.
Keywords: NSCLC, Radiotherapy resistance, Bioinformatic analysis, Bioinformatics analysis, Immunological biomarkers
Received: 10 Feb 2025; Accepted: 09 May 2025.
Copyright: © 2025 Lv, Yu, Xiong, Dai, Hu, Pan, Yue and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Changhua Yu, Department of Radiotherapy，The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical Universi, Huai’an, China
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