REVIEW article
Front. Immunol.
Sec. Nutritional Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1576118
The Influence of High-Fat Diet and Energy-Restricted Diet on Hematopoietic Stem Cells: Mechanisms and Implications
Provisionally accepted
- Army Medical University, Chongqing, China
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Increasing evidence demonstrates a close relationship between daily diet and homeostasis of the body's internal environment, particularly hematopoietic system homeostasis. Hematopoietic stem cells (HSCs) are located at the top of the hematopoietic system and have the ability to self-renew and differentiate into various types of immune cells. They play an important role in maintaining body stability and health. Studies have shown that different diets can lead to changes in HSC homeostasis, thereby affecting immune function and overall health status of the body. However, there is a scarcity of comprehensive reviews on how different diets affects HSC function. Therefore, this review summarizes the current progression in research on the effects of a high-fat diet (HFD) and energyrestricted diet on HSC function. HFD has a predominantly negative effect on HSCs, as does severe energy-restricted diet (SERD). Conversely, moderate energy-restricted diet (dietary restriction, DR) promotes the repopulation of HSCs but seriously impairs the differentiation of HSCs into lymphoid lineage. Further study of the influence of different diets on HSCs may aid in designing rational dietary guidelines to optimize the hematopoietic and immune functions of the body, which has significant implications for clinical medical practices.
Keywords: hematopoietic stem cell, high-fat diet, Dietary restriction, Protein-Energy Malnutrition, Energy
Received: 13 Feb 2025; Accepted: 13 May 2025.
Copyright: © 2025 Ang, Chen, Li, Yu, Chen and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaoling Chen, Army Medical University, Chongqing, China
Li Wang, Army Medical University, Chongqing, China
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