REVIEW article
Front. Immunol.
Sec. T Cell Biology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1583274
This article is part of the Research TopicThe Function and Regulation of T Cell Subsets in Inflammatory DiseaseView all 14 articles
Uncovering a new mechanism of ischemic stroke: a study of the association between γδ T cells and immunoinflammation
Provisionally accepted
- 1Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
- 2Tianjin University of Traditional Chinese Medicine, Tianjin, China
- 3China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China
- 4School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
- 5School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China
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Ischemic stroke, characterized by high clinical mortality and poor prognosis, has been prioritized by the World Health Organization (WHO) for reducing the burden of non-communicable diseases. However, the pathogenesis of ischemic stroke remains complex and poorly understood. Recent studies have revealed the infiltration of γδ T cells within ischemic stroke lesions, accompanied by the upregulation of IL-17, IL-23, and other inflammatory cytokines, suggesting their involvement in the stroke's pathological process.Literature indicates that γδ T cells are recruited to the lesion site by microglia-derived chemokines and subsequently infiltrate the damaged brain tissue. This review summarizes current knowledge on the precise mechanisms underlying γδ T cell activation, migration, and ensuing immune-inflammatory responses in neuroinflammation, as well as their role in the progression of ischemic stroke. It further discusses the therapeutic potential of targeting γδ T cells to modulate neuroinflammation for ischemic stroke treatment, thereby offering novel therapeutic targets for managing neuroinflammation in this condition.
Keywords: Neurology, Stroke, γδ T cells, Microglia, Immunity Model Category
Received: 25 Feb 2025; Accepted: 02 Jul 2025.
Copyright: © 2025 Sun, Wang, Gu, Guo and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Maojuan Guo, School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China
Zhen Yang, School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China
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