REVIEW article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1585280
This article is part of the Research TopicCellular and Molecular Regulators in Non-neoplastic Immune-mediated DiseasesView all 7 articles
Cytokines Unveiled: Their Impact on Oral and Multisystem Features of Lupus Erythematosus
Provisionally accepted
- 1University of Sharjah, Sharjah, United Arab Emirates
- 2King Abdulaziz University, Jeddah, Makkah, Saudi Arabia
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Systemic Lupus Erythematosus (SLE) is a multifaceted autoimmune disorder characterized by widespread inflammation and immune dysregulation, impacting various organ systems and generating autoantibodies. Oral lesions are a common and distressing manifestation of SLE, significantly affecting patients' quality of life. Cytokines, key mediators of immune responses, play a crucial role in the pathogenesis of both systemic and oral manifestations of SLE. This review sheds the light on current research on the involvement of various cytokines, including interleukins different interferon types, and growth factors in SLE. The intricate interplay between proinflammatory and anti-inflammatory cytokines contributes to the disease's initiation, progression, and diverse clinical presentations. Elevated levels of pro-inflammatory cytokines exacerbate inflammation, promote apoptosis, and drive autoantibody production. Understanding the specific roles of these cytokines offers potential therapeutic targets for managing SLE and improving patient outcomes.
Keywords: SLE, Cytokines, systemic features, Oral Features, therapeutic targets
Received: 28 Feb 2025; Accepted: 30 Jun 2025.
Copyright: © 2025 Elemam, Talaat and El Meligy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Iman Mamdouh Talaat, University of Sharjah, Sharjah, United Arab Emirates
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