REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1586892
This article is part of the Research TopicA New Perspective on the Importance of Dendritic Cells in Cancer Immunity: From Bench to Patient's BedsideView all 3 articles
Dendritic Cell-Derived Exosomes as Anti-Cancer Cell-Free Agents: New Insights into Enhancing Immunogenic Effects
Provisionally accepted
- 1Department of Genetics and Life Sciences, Sirius University, Sochi, Russia
- 2Institute of Neuroscience, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Nizhny Novgorod Oblast, Russia
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The secretome of immune cells is currently a major focus in both diagnostic and therapeutic contexts. Cell-free therapeutic agents attract even more attention in cancer immunotherapy research, as their properties are comparable to, and sometimes surpass, those of cell-based immunotherapy. This is particularly evident when dendritic cell-based vaccines are compared with dendritic cell-derived exosomes (dexosomes). However, there is still significant potential for further research and optimization. We propose incorporating immunogenic cell death stimuli into the production of dendritic cell-derived exosomes in order to improve their effectiveness as a cell-free anti-cancer treatment. In this review, we suggest a new strategy to enhance the immunogenic potential of dexosomes, as well as summarize and compare immunogenic proprieties of dendritic cells and dendritic cells-derived exosomes as anti-cancer agents.
Keywords: Extracellular vesicles1, dendritic cell-derived exosomes2, immunotherapy3, cancer treatment4, immunogenic cell death5
Received: 03 Mar 2025; Accepted: 07 May 2025.
Copyright: © 2025 Redkin and Turubanova. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tikhon Redkin, Department of Genetics and Life Sciences, Sirius University, Sochi, Russia
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.