CASE REPORT article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1591234
USE OF ANAKINRA IN CRYOPYRIN-ASSOCIATED PERIODIC SYNDROMES: CASE REPORT AND REVIEW OF LITERATURE
Provisionally accepted
Marta Salas Sanchez1*
Elena García-Martínez2Héctor Balastegui Martín3María-Esther Durán García4
Cristina Lavilla Olleros1- 1Department of Internal Medicine. Hospital General Universitario Gregorio Marañón, Madrid, Spain
- 2Immunology Department. Hospital General Universitario Gregorio Marañón, Madrid, Asturias, Spain
- 3Primary Immunodeficiencies Unit. University and Polytechnic Hospital La Fe, Valencia, Spain
- 4Pharmacy Department. Hospital General Universitario Gregorio Marañón, Madrid, Spain
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Cryopyrin-associated periodic syndrome is a rare autoinflammatory syndrome caused by a dysregulation of cytokine signaling pathways, particularly of the interleukin-1β production.Symptoms typical appear early in life and include recurrent fever, arthralgia, and cutaneous rash, often accompanied by systemic manifestations and progressive end-organ damage resulting from chronic inflammation. Interleukin-targeted therapy constitutes the basis for treatment, and can lead to complete resolution of symptoms. We report a case of a 66-yearold man with cryopyrin-associated periodic syndrome related to V198M mutation, successfully treated with anakinra, an interleukin-1 inhibitor frequently used in rheumatoid arthritis.
Keywords: Cryopyrin-associated periodic syndrome, CAPS, autoinflammatory disease, anakinra, case report
Received: 24 Mar 2025; Accepted: 15 May 2025.
Copyright: © 2025 Salas Sanchez, García-Martínez, Balastegui Martín, Durán García and Lavilla Olleros. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Marta Salas Sanchez, Department of Internal Medicine. Hospital General Universitario Gregorio Marañón, Madrid, Spain
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