REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1597210
This article is part of the Research TopicExploring KLF4's Role in Immune Cell Function and Disease ProgressionView all 6 articles
Krüppel-like factor 4 (KLF4) control of immune cell function
Provisionally accepted
- 1Brown University, Providence, Rhode Island, United States
- 2Warren Alpert Medical School, Brown University, Providence, United States
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Krüppel-like factor 4 (KLF4) belongs to a family of transcription factors that contain conserved zinc finger DNA binding domains, including specificity proteins (SPs) and Krüppel-like factors (KLFs). KLF4 plays a vital role in regulating cellular differentiation, proliferation and adaptation to a broad spectrum of internal and external cues. In the context of the immunity, KLF4 is appreciated as critical to both the innate and adaptive arms of the immune system. The current review article focuses on these aspects of KLF4 action as well as implications of this work for impacting human health.
Keywords: KLF4, immune cells, innate & adaptive immune response, SP family, homeostais
Received: 20 Mar 2025; Accepted: 02 Jul 2025.
Copyright: © 2025 Das, Wang, Xu, Yang, Liao and Jain. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mukesh K Jain, Warren Alpert Medical School, Brown University, Providence, United States
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