Your new experience awaits. Try the new design now and help us make it even better

CASE REPORT article

Front. Immunol.

Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1597365

This article is part of the Research TopicCase Reports in Autoimmune and Autoinflammatory Disorders: Volume IIView all 21 articles

DKA with negative DM-autoantibodies, complicated by GBS and RESLES：a case report and literature review

Provisionally accepted
Nan TianNan Tian1Yanwen YangYanwen Yang2Zeli MaZeli Ma1Ying WangYing Wang1Xuan LiXuan Li1Xu WangXu Wang2Yanzi JinYanzi Jin2Rong ChenRong Chen3Yajun LiYajun Li1Fenkui SheFenkui She1Fenglin MouFenglin Mou1Qing ZhangQing Zhang2,4*
  • 1Ningxia Medical University, Yinchuan, China
  • 2General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Region, China
  • 3Department of Neuroelectrophysiology, Cardiovascular and Cerebrovascular Disease Hospital Branch, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia Province, China
  • 4Neurology center, General Hospital of Ningxia Medical University, Yinchuan, China

The final, formatted version of the article will be published soon.

Select one of your emails

You have multiple emails registered with Frontiers:

Notify me on publication

Please enter your email address:

If you already have an account, please login

You don't have a Frontiers account ? You can register here

【Abstract】Guillain-Barré syndrome (GBS) is an autoimmune-mediated disorder characterized by by acute, multifocal peripheral neuropathies, typically triggered by infections, autoimmune diseases, or immunosuppressive therapies. In this report, we describe a patient newly diagnosed with diabetes mellitus (DM) and diabetic ketoacidosis (DKA), who presented with negative insulin-related autoantibodies and no identifiable infectious etiology. It is suggested that DKA may independently contribute to the development of GBS. Additionally, DKA can lead to the reversible splenial lesion syndrome (RESLES). We present a case of GBS with atypical features consistent with the acute motor axonal neuropathy (AMAN) variant.

Keywords: GBS, DM, DKA, RESLES, Autoantibody-negative

Received: 26 Mar 2025; Accepted: 31 Aug 2025.

Copyright: © 2025 Tian, Yang, Ma, Wang, Li, Wang, Jin, Chen, Li, She, Mou and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Qing Zhang, Neurology center, General Hospital of Ningxia Medical University, Yinchuan, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material