CASE REPORT article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1601700
This article is part of the Research TopicCommunity Series: Systemic Vasculitis: Advances in Pathogenesis and Therapies Volume IIView all 7 articles
Severe Gastrointestinal Complications in Adult IgA vasculitis: A Fatal Case of Acute Esophageal Necrosis
Provisionally accepted
- 1Army Medical University, Chongqing, China
- 2First Affiliated Hospital of Chongqing Medical University, Chongqing, Chongqing Municipality, China
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Henoch-Schönlein Purpura (HSP), also known as Immunoglobulin A vasculitis(IgAV),is a type of systemic small vessel inflammatory pathology,clinical symptoms can range from simple skin purpura to multi-organ damage. IgAV can be divided into cutaneous-limited and multi-system-involved types, with significant individual variability in clinical manifestations. Between 50-75% of patients experience abdominal symptoms such as abdominal pain and hematochezia, however, the occurrence of IgAV complicated by pancreatitis and esophageal mucosal sloughing is exceedingly rare. We report a case of adult IgAV with widespread purpura as the main clinical manifestation. Abdominal pain emerged during treatment, and pancreatitis was initially diagnosed according to serum amylase findings and CT imaging features. Nevertheless, acute esophageal necrosis was confirmed via gastroscopy, followed by a rapid deterioration in the patient's clinical status within a short period, ultimately leading to death due to massive gastrointestinal(GI) bleeding and disseminated intravascular coagulation (DIC).
Keywords: Henoch-Schönlein purpura, Immunoglobulin A, Acute esophageal necrosis, Pancreatitis, acute abdomen
Received: 29 Apr 2025; Accepted: 07 Oct 2025.
Copyright: © 2025 Shao, Zhang, Wu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shifeng Shao, shaosf@tmmu.edu.cn
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