REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1604837
This article is part of the Research TopicLipid-Immune Interplay in Chronic Inflammatory-Based DisordersView all 6 articles
TREM2 in MASH: Integrating Lipid Metabolism and Immune Response
Provisionally accepted
- 1Huazhong University of Science and Technology, Wuhan, China
- 2Wuhan Union Hospital, Wuhan, Hebei Province, China
- 3Central Hospital of Wuhan, Huazhong University of Science and Technology, Wuhan, Hebei Province, China
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Metabolic dysfunction-Associated Steatohepatitis (MASH), a progressive liver disease characterized by disturbances of lipid metabolism and chronic inflammation response in liver has become the most prevalent chronic liver diseases worldwide. Recent single-cell transcriptomic studies in both humans and mice have identified a distinct population of liver macrophages characterized by the expression of Triggering Receptor Expressed on Myeloid Cells 2 (TREM2), also be known as lipid-associated macrophages (LAMs), is highly expressed in macrophages under metabolic stress conditions. Several studies have demonstrated that TREM2+ macrophages play a crucial role in lipid metabolism and immune responses, contributing to the reversal of MASH. This review provides a comprehensive overview of the current evidence on the roles of TREM2+macrophages in regulating lipid metabolism and immune responses in MASH, with emphasis on the functions of TREM2+ macrophages in lipid handling and inflammation regulation, which could provide novel insights into the pathogenesis of MASH and inform targeted therapeutic strategies.
Keywords: Metabolic dysfunction -Associated Steatohepatitis (MASH), Triggering Receptor Expressed on Myeloid cells-2(TREM2), Lipid-associated Macrophages (LAMs), Lipid Metabolism, immune response
Received: 02 Apr 2025; Accepted: 10 Jun 2025.
Copyright: © 2025 Zhang, Shi, Zhou and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Junli Zhang, Huazhong University of Science and Technology, Wuhan, China
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