REVIEW article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1608909
This article is part of the Research TopicImmunomodulation of the Immune System by Phytochemicals: Exploring the Therapeutic Potential of Natural CompoundsView all articles
Therapeutic Mechanisms of Polysaccharides in the Management of Rheumatoid Arthritis: A Comprehensive Review
Provisionally accepted
- 1Graduate School, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
- 2First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
AbstractRheumatoid Arthritis (RA) is a chronic autoimmune disease characterised by synovial inflammation and destruction of articular cartilage and bone, which seriously affects patients' quality of life. In recent years, with the in-depth research on natural medicines, the application of polysaccharides in the treatment of RA has gradually gained attention due to their unique bioactive components and diverse pharmacological effects. Polysaccharides were reported to exert anti-inflammatory, antioxidant, immunomodulatory, and protective effects on cartilage and bone tissues. This review briefly introduces RA, its etiology and pathogenesis, and the different sources and structures of polysaccharides. It focuses on the mechanisms of polysaccharides in the alleviation of RA, mainly through the modulation of immune cell function, inhibition of inflammation, regulation of gut microbiota, promotion of bone formation and repair, and influence on related pathways. The aim of this review is to summarize the polysaccharides and their mechanisms of action in the alleviation of RA, with a view to providing new ideas for the clinical treatment of RA.
Keywords: rheumatoid arthritis (RA), Polysaccharides, Mechanism, immune cells, Cytokines
Received: 09 Apr 2025; Accepted: 12 Jun 2025.
Copyright: © 2025 Liu, Kong, Wang, Yang, Yan and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zeguang Li, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.