Immunomodulation of the immune system by phytochemicals: Exploring the therapeutic potential of natural compounds

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ORIGINAL RESEARCH

Published on 11 Dec 2025

Macrophage activation of the TREM2-DAP12-SYK pathway shapes the adipose tissue microenvironment in obesity and unveils the therapeutic potential of natural compounds egcg and SMRR

Wang Luoying
Yi Xingcheng
Cong Donghang
Long Mengtuan
Wang Ping
Zhang Lijuan
Li Yupeng
Zhao Tianyi
Chen Hongyu
5 more
Su Xiaoyun

doi 10.3389/fimmu.2025.1694985

1,451 views

REVIEW

Published on 11 Nov 2025

Phytochemicals as modulators of dendritic cell functions: implications for tolerogenic cell-based therapy

Tünde Fekete
Kitti Pázmándi

doi 10.3389/fimmu.2025.1653803

1,957 views

ORIGINAL RESEARCH

Published on 13 Oct 2025

Comparative study of the anti-inflammatory effect and acute toxicity of Sacha Inchi oils (Plukenetia volubilis and Plukenetia huayllabambana) in mice

Jose Luis Aguilar-Olano
Silvia Davila Paico
Christian Pitot Alvarez

doi 10.3389/fimmu.2025.1641344

1,472 views

REVIEW

Published on 27 Aug 2025

Natural antidepressants in neuroimmunomodulation: molecular mechanisms, action targets, and therapeutic potential

Shimeng Lv
Linghui Kong
Xia Zhong
Ruirui Shang
Yitong Lu
Guangheng Zhang
Haonan Gao
Xin Hou
Guoqiang Li
Xiaowen Yu

doi 10.3389/fimmu.2025.1642001

2,450 views
1 citation

ORIGINAL RESEARCH

Published on 21 Aug 2025

Promotion of Treg/Th17 balance in MRL/lpr mice by Jianpi-Zishen Formula via modulation of DNMT1-mediated Foxp3 methylation

Ming Li
Lijun Pang
Yunfei Li
Junjie Chen
Shuangshuang Shang
Chuanbing Huang

doi 10.3389/fimmu.2025.1631631

2,267 views

REVIEW

Published on 01 Jul 2025

Therapeutic mechanisms of polysaccharides in the management of rheumatoid arthritis: a comprehensive review

Wenlong Liu
Youqian Kong
Xiaoyu Wang
Yuanyuan Yang
Qi Yan
Zeguang Li

doi 10.3389/fimmu.2025.1608909

2,675 views
1 citation

ORIGINAL RESEARCH

Published on 17 Jun 2025

Differential metabolic pathways underlie THC- and CBD-mediated inhibition of B-cell activation in both young and aged mice

Zhanna Yekhtin
Dmytro Petukhov
Iman Khuja
Natalya M. Kogan
Reuven Or
Osnat Almogi-Hazan

doi 10.3389/fimmu.2025.1605474

2,278 views
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Frontiers in Immunology

Immunological Tolerance and Regulation

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Articles

Macrophage activation of the TREM2-DAP12-SYK pathway shapes the adipose tissue microenvironment in obesity and unveils the therapeutic potential of natural compounds egcg and SMRR

Phytochemicals as modulators of dendritic cell functions: implications for tolerogenic cell-based therapy

Comparative study of the anti-inflammatory effect and acute toxicity of Sacha Inchi oils (Plukenetia volubilis and Plukenetia huayllabambana) in mice

Natural antidepressants in neuroimmunomodulation: molecular mechanisms, action targets, and therapeutic potential

Promotion of Treg/Th17 balance in MRL/lpr mice by Jianpi-Zishen Formula via modulation of DNMT1-mediated Foxp3 methylation

Therapeutic mechanisms of polysaccharides in the management of rheumatoid arthritis: a comprehensive review

Differential metabolic pathways underlie THC- and CBD-mediated inhibition of B-cell activation in both young and aged mice

Frontiers in Immunology

Immunological Tolerance and Regulation