REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1610121
This article is part of the Research TopicCommunity Series in Crosstalk in Ferroptosis, Immunity & Inflammation: Volume IIView all articles
Targeting the Ferroptosis Pathway for Rheumatoid Arthritis: Molecular Mechanisms and Prospects for Inhibitor Development
Provisionally accepted
卓灵 王1
Bai Xinyue1
Huahua Zhang1Min Yang1Meilin Liu1Tingyu Nie1Tianjiao Li1Mingru Zhang1Xingdan Wang1Jin Wang2*
Jiming Han1*
Xiao-Long Liu1*- 1Yan'an University, Yan'an, China
- 2Yanan University Affiliated Hospital, Yanan, Shaanxi, China
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Abstract：Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease with severe complications. Ferroptosis, an iron-dependent form of apoptosis, encompasses mechanisms including iron overload, lipid peroxidation, redox homeostasis, and reactive oxygen species accumulation, all of which are closely related to RA pathogenesis. This study focused on the mechanism of ferroptosis and RA, detailing their relationship and outlining the reported roles of ferroptosis inhibitors in RA treatment to provide a useful research basis in drug discovery and development and for clinicians.
Keywords: ferroptosis, Rheumatoid arthritis, Lipid Peroxidation, Natural medicine, Nanomedicine
Received: 11 Apr 2025; Accepted: 23 May 2025.
Copyright: © 2025 王, Xinyue, Zhang, Yang, Liu, Nie, Li, Zhang, Wang, Wang, Han and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jin Wang, Yanan University Affiliated Hospital, Yanan, 716000, Shaanxi, China
Jiming Han, Yan'an University, Yan'an, China
Xiao-Long Liu, Yan'an University, Yan'an, China
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