PERSPECTIVE article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1610662
Decoding the etiology of immune-mediated inflammatory diseases statistically
Provisionally accepted
Hesham ElAbd*
Aya K H Mahdy- Institute of Clinical Molecular Biology, Faculty of Medicine, University of Kiel, Kiel, Schleswig-Holstein, Germany
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Immune-mediated inflammatory diseases (IMIDs) are incurable pathologies with an increased prevalence. Whereas different risk factors for IMIDs have been identified, such as microbial dysbiosis, diet, Epstein-Barr virus infection, the exact cause of most of these diseases remains unknown and it is thought to be a combination of environmental exposures and genetic predispositions. Despite their different clinical presentation, most IMIDs are genetically associated with variants at multiple immune-related genes, predominately with different human leukocyte antigen (HLA) alleles suggesting a strong pathological involvement of adaptive immune responses. However, antigens causing these diseases remain, in most
Keywords: immune-mediated inflammatory diseases, immune repertoire, T-cell repertoire profiling, T-cell therapies, Statistical analyses, etiology, Immunogenetics
Received: 12 Apr 2025; Accepted: 12 May 2025.
Copyright: © 2025 ElAbd and Mahdy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hesham ElAbd, Institute of Clinical Molecular Biology, Faculty of Medicine, University of Kiel, Kiel, 24105, Schleswig-Holstein, Germany
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