Editorial: Unveiling nature's arsenal against inflammation and autoimmunity

Mohamed El-Shazly¹Jiao Xiao²Jian Chen^3*

• ¹Ain Shams University, Cairo, Cairo, Egypt
• ²Shenyang Pharmaceutical University, Shenyang, Liaoning Province, China
• ³Shenzhen Hospital, Peking University, Shenzhen, China

In this context, the realm of natural products and their derivatives emerges as a treasure trove of potential solutions. For centuries, traditional medicine systems have harnessed the power of nature to alleviate a myriad of ailments, and modern science is increasingly validating these time-honored practices. Natural products, particularly their structurally diverse monomer compounds, exhibit a remarkable array of biological activities, positioning them as invaluable sources of novel drugs and promising lead compounds for innovative drug development.Over recent decades, researchers have achieved significant breakthroughs across chemical sciences, pharmaceutical resources, pharmacological studies, formulation technologies, and novel drug discovery. The remarkable story of Professor Tu You-You and her Nobel Prizewinning discovery of artemisinin serves as a powerful testament to the transformative potential of natural product research. Initially identified for its anti-malarial properties, artemisinin and its analogs have since demonstrated a broader spectrum of activities, including compelling antiinflammatory and immunomodulatory effects with promising applications in the treatment of immune-related disorders [2]. This success story underscores the vast, yet largely untapped, potential residing within the natural world for addressing complex human diseases. This special issue titled "Natural Products and Their Derivatives in the Treatment of Inflammatory and Autoimmune Diseases" aims to highlight the exciting advancements in this critical area of research. We have gathered a collection of insightful perspectives, cutting-edge original research articles, comprehensive reviews, and thought-provoking commentaries that delve into the functional implications of natural products and their derivatives in combating the intricate challenges of inflammatory and autoimmune conditions.The contributions within this issue showcase the breadth and depth of ongoing investigations. From comprehensive reviews exploring the multifaceted therapeutic potential of compounds like artemisinin in rheumatic and autoimmune disorders to preclinical studies evaluating the immunomodulatory effects of herbal medicines in neurodegenerative conditions such as amyotrophic lateral sclerosis, the articles presented here underscore the diverse applications of natural products [3]. Furthermore, investigations into the quality and potential biases in clinical trials of traditional Chinese medicine for multiple sclerosis highlight the importance of rigorous scientific evaluation in this field.Several articles within this special issue delve into the specific molecular mechanisms by which natural products exert their beneficial effects. Studies targeting post-stroke neuroinflammation with Salvianolic acid A and exploring the anti-inflammatory potential of phenolic acids from medicinal plants exemplify this mechanistic focus [4,5]. In addition, Zheng's group reported that Chinese herbal medicine represented the potential for the treatment of amyotrophic lateral sclerosis (ALS) and MS [6,7]. Moreover, investigations into the effects of oral curcumin in models of inflammatory bowel disease and the immuno-modulatory role of baicalin in atherosclerosis further illustrate the diverse therapeutic targets and mechanisms of action of natural compounds [8,9]. Furthermore, Chinese medicine PaBing-II showed a notable protective effect on human induced pluripotent stem cell (iPSC)-derived dopaminergic neurons [10]. Beyond direct therapeutic applications, this special issue also emphasizes the crucial role of cutting-edge methodologies in advancing the field. The application of network pharmacology and genetic sequencing for identifying potential biomarkers and novel drug targets in inflammatory and autoimmune diseases holds immense promise for developing more precise and effective treatments.The collection of papers presented in this special issue underscores the significant progress being made in harnessing the power of natural products to address the persistent challenges of inflammatory and autoimmune diseases. We are confident that the research highlighted herein will not only contribute to a deeper understanding of the therapeutic potential of natural compounds but will also inspire further investigation and ultimately pave the way for the discovery of novel drugs with independent intellectual property rights, offering new hope for patients suffering from these debilitating conditions. We extend our sincere gratitude to all the contributing authors for their valuable insights and rigorous research, and to the reviewers for their dedication and expertise in ensuring the high quality of this special issue. We hope that this collection will serve as a valuable resource for