SYSTEMATIC REVIEW article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1617157
This article is part of the Research TopicNew Insights into Inflammation Driven Autoimmune Skin Disorders: Trends and ChallengesView all 7 articles
Adipose-derived mesenchymal stem cells (ADMSCs) and their derivatives in inflammatory skin diseases: a systematic review
Provisionally accepted
- 1Department of Dermatology and Venereology, Medical University of Bialystok, Bialystok, Poland
- 2Medical University of Bialystok, Bialystok, Podlaskie Voivodeship, Poland
- 3Department of Physiology, Medical University of Bialystok, Bialystok, Poland
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Adipose-derived mesenchymal stem cells (ADMSCs) offer a multifaceted approach to treating immune-mediated skin diseases by modulating the immune system and promoting tissue regeneration. have emerged as a promising therapeutic option due to their unique properties and potential applications in various fields, including tissue regeneration, immunomodulation, and drug delivery. Specifically, their ability to differentiate into multiple cell types such as keratinocytes and fibroblasts, modulate immune responses, and release growth factors and cytokines underscores their potential in treating a wide range of immune-related skin conditions. They can modulate immune response via T cells, B cells and macrophages. ADMSCs significantly reduced various aspects of psoriasis, including scaling, thickness, and erythema. Moreover, cell-free therapy has even better therapeutic potential. It has been shown that ADMSC-derived exosomes can effectively alleviate pathological symptoms of atopic dermatitis, including clinical score, serum IgE levels, eosinophil amount, and infiltration of immune cells in skin lesions. This systematic review summarizes the most relevant preclinical and clinical studies on the therapeutic use of ADMSCs and their small extracellular vesicles in the treatment of common skin diseases like psoriasis, atopic dermatitis, localized scleroderma and acne vulgaris.
Keywords: ADMSCs, Small extracellular vesicles, Exosomes, Skin Diseases, Psoriasis, atopic dermatitis, Localized scleroderma, Acne Vulgaris
Received: 23 Apr 2025; Accepted: 07 Aug 2025.
Copyright: © 2025 Matwiejuk, Miklosz, Myśliwiec, Chabowski and Flisiak. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mateusz Matwiejuk, Department of Dermatology and Venereology, Medical University of Bialystok, Bialystok, 15-540, Poland
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.