MINI REVIEW article
Front. Immunol.
Sec. T Cell Biology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1622928
Regulation of Actin Cytoskeletal Dynamics in T cell Development and Function
Provisionally accepted
- St Vincent's Institute of Medical Research, Fitzroy, Australia
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T cell development and function depend on precise remodeling of the actin cytoskeleton, which regulates migration, cell division, immunological synapse formation, and signal transduction. Regulators of actin include nucleators (Arp2/3, Formins) and binding proteins (coronins, cofilin, myosin) that orchestrate cytoskeletal dynamics to ensure efficient antigen recognition and signaling, while Rho GTPases (Rac1, Cdc42, RhoA) link extracellular cues to actin rearrangements, influencing both conventional T cell activation and function. Dysregulated actin dynamics contribute to immunodeficiencies and autoimmunity, and thus understanding how the actin cytoskeleton is regulated in T cells has important implications.
Keywords: T cells, T cell development, Coronin, actin cytoskeletal dynamics, actin-binding proteins, Immunological Synapse
Received: 05 May 2025; Accepted: 26 May 2025.
Copyright: © 2025 Chong and Lam. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mark M W Chong, St Vincent's Institute of Medical Research, Fitzroy, Australia
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