MINI REVIEW article
Front. Immunol.
Sec. Molecular Innate Immunity
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1625368
This article is part of the Research TopicRole of Endogenous Regulators of Innate Immunity in SepsisView all 8 articles
Dopamine as an endogenous regulator of innate immunity in sepsis
Provisionally accepted
- 1Feinstein Institute for Medical Research, New York, United States
- 2Department of Surgery, UT Southwestern Medical Center, Dallas, Texas, 75390, USA, Dallas, United States
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Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, presents a major clinical challenge. While the complex interplay of inflammatory mediators and immune cells during sepsis is increasingly understood, the role of neurotransmitters, particularly dopamine, in modulating the innate immune response is emerging as a crucial area of investigation. Dopamine, traditionally recognized for its role in the central nervous system, acts as an endogenous regulator of innate immunity, significantly influencing the course and outcome of sepsis. In this mini-review, we highlight our recent finding of dopamine's critical role in regulating aconitate decarboxylase 1 (ACOD1) in sepsis.
Keywords: Dopamine, Sepsis, aconitate decarboxylase 1, CD274, Innate immunity
Received: 08 May 2025; Accepted: 20 Jun 2025.
Copyright: © 2025 Wang, Kang and Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Haichao Wang, Feinstein Institute for Medical Research, New York, United States
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