SYSTEMATIC REVIEW article

Front. Immunol.

Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1628928

Associated Factors in the Development of Rapidly Progressive Interstitial Lung Disease in Patients with Idiopathic Inflammatory Myopathies: A Systematic Review and Meta-Analysis

Provisionally accepted
Weiwei YuanWeiwei Yuan1Xuefei ZhouXuefei Zhou2Yahui YangYahui Yang3Shijie ZhangShijie Zhang4,5Xing HeXing He4,5Jiaqi JiJiaqi Ji6*
  • 1School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, Chengdu, China, China
  • 2Department of Pediatrics, The First People's Hospital of Shuangliu District / West China (Airport) Hospital Sichuan University, Chengdu, China, Chengdu,China, China
  • 3School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, Chengdu，China, China
  • 4Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China, Chengdu，China, China
  • 5State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, China., Chengdu，China, China
  • 6Department of Pulmonary and Critical Care Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China., Chengdu，China, China

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Interstitial lung disease (ILD), the main pulmonary manifestation of idiopathic inflammatory myopathy (IIM), frequently develops into rapidly progressive ILD (RP-ILD) with significantly worse prognosis. This meta-analysis identifies associated risk and protective factors for developing RP-ILD in IIM patients.We searched PubMed, Embase, Web of Science, and Scopus (up to October 2024), analyzing 21 retrospective studies (2,099 patients). Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were collected. Subgroup analysis was performed based on RP-ILD definition. Sensitivity analysis and publication bias assessments (Egger's test, trim-and-fill method) were performed.The associated risk factors for RP-ILD development in IIM patients included age (OR

Keywords: Idiopathic inflammatory myopathy, Rapidly progressive interstitial lung disease, development, Associated factors, Anti-MDA5

Received: 15 May 2025; Accepted: 14 Jul 2025.

Copyright: © 2025 Yuan, Zhou, Yang, Zhang, He and Ji. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Jiaqi Ji, Department of Pulmonary and Critical Care Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China., Chengdu，China, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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