REVIEW article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1633752
Crossing the metabolic homeostasis divide: panoramic decoding of therapeutic targets for metabolic-inflammatory crosstalk in rheumatoid arthritis
Provisionally accepted
- 1Anhui University of Chinese Medicine First Clinical Medical College, Hefei, China
- 2The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China
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Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and joint destruction. Its pathogenesis is closely related to the imbalance of glycolipid metabolism. This article reviews the pathophysiological mechanisms of glycolipid metabolism in the RA pathogenesis, focusing on the physiological mechanisms of glucose and lipid metabolism as well as the characteristics of glycolipid metabolism imbalance and their interactions in RA. Moreover, this study highlights the relationship between specific glycolipid metabolism markers and disease activity, as well as the innovative targets and intervention strategies of glycolipid metabolism modulation in the RA treatment. Studies show that RA patients have over-activated glycolytic pathways and disrupted lipid metabolism. These metabolic changes drive the inflammatory response and joint destruction and are also strongly associated with disease activity. Through a deeper understanding of the key nodes and regulatory mechanisms of glycolipid metabolism in RA, this article might provide new ideas for the precise diagnosis and treatment of RA.
Keywords: Rheumatoid arthritis, glucose metabolism, Lipid Metabolism, Inflammations, Immunity, Target of intervention
Received: 23 May 2025; Accepted: 27 Aug 2025.
Copyright: © 2025 Liang, Wan, Wang, Zhang, Wang, Min and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lei Wan, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China
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