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CORRECTION article

Front. Immunol., 26 November 2025

Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Volume 16 - 2025 | https://doi.org/10.3389/fimmu.2025.1704527

Correction: Crossing the metabolic homeostasis divide: panoramic decoding of therapeutic targets for metabolic-inflammatory crosstalk in rheumatoid arthritis

Siyu Liang,Siyu Liang1,2Lei Wan*Lei Wan2*Siyu WangSiyu Wang2Mengyu ZhangMengyu Zhang2Ying WangYing Wang2Wenwen MinWenwen Min2Yu ZhangYu Zhang2
  • 1The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui, Hefei, China
  • 2Anhui University of Chinese Medicine First Clinical Medical College, Anhui, Hefei, China

A Correction on
Crossing the metabolic homeostasis divide: panoramic decoding of therapeutic targets for metabolic-inflammatory crosstalk in rheumatoid arthritis

By Liang S, Wan L, Wang S, Zhang M, Wang Y, Min W and Zhang Y (2025). Front. Immunol. 16:1633752. doi: 10.3389/fimmu.2025.1633752

There was a mistake in Figure 3 as published. During post-publication review, Figures 2 and 3 were identified as requiring improvement for clarity and coherence. To provide a more concise and integrated visualization, both figures have been removed and replaced with a single updated and fully original figure. This modification does not affect the scientific conclusions of the article. The corrected Figure 2 and its caption appears below.

Figure 2
Biochemical pathway illustration showing the interactions between glucose, glucagon, insulin, and their effects on cellular processes. Pathways include glycolysis, gluconeogenesis, and the TCA cycle. Molecules like ATP, NADH, and various enzymes are depicted influencing processes like cholesterol and amino acid synthesis. Arrow directions indicate process flow and relationships.

Figure 2. Core pathways of glucose metabolism and their dynamic synergistic networks. Glucose metabolism integrates glycolysis, the tricarboxylic acid (TCA) cycle, and amino acid and lipid synthesis. Insulin activates the PI3K–Akt–mTOR pathway to enhance glucose uptake and glycolysis, whereas glucagon promotes gluconeogenesis through the cAMP–PKA cascade. The TCA cycle acts as a metabolic hub linking carbohydrate, amino acid, and lipid metabolism through acetyl-CoA and key intermediates.

The original version of this article has been updated.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Keywords: rheumatoid arthritis, glucose metabolism, lipid metabolism, inflammations, immunity, target of intervention

Citation: Liang S, Wan L, Wang S, Zhang M, Wang Y, Min W and Zhang Y (2025) Correction: Crossing the metabolic homeostasis divide: panoramic decoding of therapeutic targets for metabolic-inflammatory crosstalk in rheumatoid arthritis. Front. Immunol. 16:1704527. doi: 10.3389/fimmu.2025.1704527

Received: 13 September 2025; Accepted: 14 November 2025;
Published: 26 November 2025.

Edited and reviewed by:

Betty Diamond, Feinstein Institute for Medical Research, United States

Copyright © 2025 Liang, Wan, Wang, Zhang, Wang, Min and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Lei Wan, eXh3YW5sZWlAMTYzLmNvbQ==

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.