MINI REVIEW article
Front. Immunol.
Sec. Immunological Memory
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1639732
Targeting the IL-15/CD122 Signaling Pathway: Reversing TRM Cell-Mediated Immune Memory in Vitiligo
Provisionally accepted
- Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
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Vitiligo is a chronic autoimmune disorder in which melanocyte-specific CD8⁺ T cells destroy pigment-forming cells, producing persistent depigmented macules. Recurrence after treatment implicates tissue-resident memory T (TRM) cells that are maintained by interleukin-15 (IL-15) signaling. Here we review current insights into TRM-cell biology, summarize experimental and emerging clinical data targeting the IL-15/CD122 axis-including the ongoing Phase 2a AMG 714 trial-and discuss combination strategies with approved topical Janus kinase inhibitors such as ruxolitinib cream. Disrupting IL-15 may offer durable repigmentation with minimal systemic immunosuppression.
Keywords: Vitiligo, tissue-resident memory T cell, IL-15, CD122, Ruxolitinib, AMG 714
Received: 02 Jun 2025; Accepted: 14 Jul 2025.
Copyright: © 2025 Su and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Fang Liu, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
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