REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1641132
This article is part of the Research TopicLipid-immune interplay in chronic inflammatory-based disordersView all 9 articles
The NLRP3 Inflammasome: A Pivotal Orchestrator of Multisystem Diseases — From Molecular Mechanisms to Therapeutic Innovation
Provisionally accepted
- 1Medical school of Chinese PLA, Beijing, China
- 2Fifth Medical Center of the PLA General Hospital, Beijing, China
- 3Second Affiliated Hospital of Anhui Medical University, Hefei, China
- 45th Medical Center of Chinese PLA General Hospital Senior Department of Oncology, Fengtai, China
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The NLRP3 inflammasome, a key regulatory element in the innate immune system, connects pathogen recognition to chronic disease pathogenesis through modulation of pyroptosis, inflammatory cytokine release, and metabolic homeostasis. Given its central role in inflammatory cascades, this molecular complex has been positioned as a prime therapeutic target. This review delineates pathological contributions of the NLRP3 inflammasome to multisystem disorders—encompassing neurological, cardiovascular, respiratory, gastrointestinal, urological, metabolic, and autoimmune conditions—while systematically evaluating associated therapeutic strategies. Furthermore, classical activation pathways of this molecular complex are consolidated, and targeted inhibition approaches directed against both the inflammasome and its downstream effectors are discussed. Collectively, a critical framework is established for understanding disease mechanisms and advancing translational interventions.
Keywords: NLRP3 inflammasome, pyroptosis, Multisystem diseases, Inflammatory signaling pathways, therapeutic inhibitors
Received: 04 Jun 2025; Accepted: 09 Oct 2025.
Copyright: © 2025 Xiao, Lv, Ji, Dong, Liu, Cui and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaoran Cui, cooboozhi@gmail.com
Yi Hu, huyi301zlxb@sina.com
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