Correction: Experimental models for developing oncolytic virotherapy for metastatic prostate cancer

There was a mistake in Table 1 as published. There should be a separation slash between “Models and Hosts” and “Viruses”. The corrected Table 1 appears below.

The virus particle unit number was incorrect.

A correction has been made to the section Platforms to determine oncolytic virus cytotoxicity in prostate cancer, Focus on five-year clinical trials of OVs in prostate cancer, paragraph 3:

“The modified oncolytic adenovirus Ad5-yCD/mutTK_SR39rep-hIL-12 was evaluated for its dosage tolerance and safety in a phase I clinical trial involving 15 patients with localized recurrent prostate cancer. A single intraprostatic dose of the virus, ranging from 1 × 10¹⁰ to 1 × 10¹² viral particles, was administered on the first day of the trial, then followed by seven days of 5-fluorocytosine (5-FC) and valganciclovir (vGCV) chemotherapy (51). The Ad was designed to express cytosine deaminase (CD) and HSV thymidine kinase (TK), which convert the pro-drugs 5-FC and GCV into toxic agents that eliminate the cancer cells by interfering with DNA synthesis. The safety of this treatment was confirmed, with no reported DLTs, and 92% of side effects were classified as either grade 1 (mild) or grade 2 (moderate). Also, elevated levels of CD3^-CD56⁺ NK cells, CD3⁺CD4⁺ T helper cells, and CD3⁺CD8⁺ cytotoxic T cells were observed in patients, suggesting immune modulation in peripheral blood due to IL-12 expression from the Ad (104).”

The virus particle unit number was missing.

A correction has been made to the section Trends of oncolytic viral therapy in cancer, Neutralization and clearance of OV within the system, paragraph 1:

“Throughout history, humans have co-evolved with viruses, and it may come as a surprise that over 50% of the human genome originates from viruses and transposable elements. These genetic materials, acquired through horizontal gene transfer, crossover and recombination, and transformation, have significantly shaped who we are today (123), including our immunity. Over time, the diversity of the major histocompatibility complex (MHC) has further impacted T cell and B cell specificity, as well as antibody production, thus strengthening our immune response to pathogens (124, 125). In a study by Alemany et al. in 2000 (10), it was reported that 10¹⁰ transducing units (t.u.) of adenovirus serotype 5 particles have a half-life of less than 2 minutes following vena cava injection, with viral sequences being cleared by Kupffer cells in the liver within 24 hours (126). To prolong circulation time, scientists have genetically engineered viruses, equipping them with inhibitors of CD8+ T cells (127) or NK cell activation (128). Similarly, disguising the virus using polyethylene glycol (PEG) (for Ad and VSV) or using mesenchymal stromal/stem cells (MSCs) as viral carriers has been shown also to prevent rapid clearance, thereby extending circulation time (126, 129–131). Protected virus not only extend their effective duration in the system but also enhance their migration toward target sites by reducing accumulation in the liver (129, 131). While rapid neutralization of oncolytic viruses might seem counter-intuitive as a therapeutic strategy, it could act to enhance immune cell infiltration into tumors, thereby improving therapeutic outcomes (132, 133).”

The original version of this article has been updated.

Statements

Summary

Keywords

oncolytic virus, metastatic prostate cancer, immunotherapy, virotherapy, experimental models

Citation

Chen Y-C and Figueiredo ML (2025) Correction: Experimental models for developing oncolytic virotherapy for metastatic prostate cancer. Front. Immunol. 16:1665709. doi: 10.3389/fimmu.2025.1665709

Received

14 July 2025

Accepted

21 July 2025

Published

11 August 2025

Volume

16 - 2025

Edited and reviewed by

Pratik Bhojnagarwala, Wistar Institute, United States

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Copyright

© 2025 Chen and Figueiredo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Marxa Leão Figueiredo, mlfiguei@purdue.edu

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