MINI REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1667122
This article is part of the Research TopicImmune Landscape in the Transition from Inflammation to TumorigenesisView all 10 articles
Exosomes in Epilepsy: Bridging Neuroinflammation, Diagnosis, and Therapeutic Delivery
Provisionally accepted
- 1Department of Neurology, The Second Hospital & Clinical Medical School.Lanzhou University, Lanzhou, 730030, China, Lanzhou, China
- 2Department of Respiratory, The Second Hospital & Clinical Medical School.Lanzhou University, Lanzhou, 730030, China, Lanzhou, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Epilepsy, as a chronic neurological disorder marked by recurrent seizures, is closely linked to neuroinflammation and immune dysregulation. Exosomes, extracellular vesicles with potent immunomodulatory properties, have emerged as key players in mitigating epilepsy-associated inflammation by targeting glial activation and balancing pro-and anti-inflammatory cytokine release. Their ability to cross the blood-brain barrier (BBB) enables targeted delivery of anti-inflammatory cargo, such as miRNAs and proteins, offering promise for diagnosing and treating drug-resistant epilepsy. This review highlights exosomes' dual role as biomarkers of inflammatory pathways and therapeutic vehicles for immune modulation. By suppressing neuroinflammation and restoring neuronal homeostasis, exosome-based strategies may revolutionize epilepsy management, though clinical translation requires further optimization of isolation and engineering techniques.
Keywords: Epilepsy, Exosomes, Blood-Brain Barrier, Neuroinflammation, drug-resistance, Drug delivery
Received: 16 Jul 2025; Accepted: 26 Aug 2025.
Copyright: © 2025 Li, Zhu, Chen, Cui and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhenchang Zhang, Department of Neurology, The Second Hospital & Clinical Medical School.Lanzhou University, Lanzhou, 730030, China, Lanzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.