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CORRECTION article

Front. Immunol., 21 August 2025

Sec. Inflammation

Volume 16 - 2025 | https://doi.org/10.3389/fimmu.2025.1672460

Correction: RG100204, a novel Aquaporin-9 inhibitor, reduces septic cardiomyopathy and multiple organ failure in murine sepsis

This article is a correction to:

  1. RG100204, A Novel Aquaporin-9 Inhibitor, Reduces Septic Cardiomyopathy and Multiple Organ Failure in Murine Sepsis

    1. Read original article
Shireen Mohammad*Shireen Mohammad1*Caroline E. O&#x;RiordanCaroline E. O’Riordan1Chiara VerraChiara Verra1Eleonora AimarettiEleonora Aimaretti2Gustavo Ferreira AlvesGustavo Ferreira Alves3Klaus DreischKlaus Dreisch4Johan EvensJohan Evenäs4Patrizia GenaPatrizia Gena5Angela TesseAngela Tesse6Michael Rützler,Michael Rützler7,8Massimo CollinoMassimo Collino3Giuseppe CalamitaGiuseppe Calamita5Christoph Thiemermann*Christoph Thiemermann1*
  • 1William Harvey Research Institute, Queen Mary University of London, London, United Kingdom
  • 2Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
  • 3Department of Neurosciences “Rita Levi Montalcini”, University of Turin, Turin, Italy
  • 4Red Glead Discovery Akiebolag (AB), Lund, Sweden
  • 5Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari “Aldo Moro”, Bari, Italy
  • 6Nantes Université, Instite National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Rescherche Scientifique (CNRS), l’institut du Thorax, Nantes, France
  • 7Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden
  • 8Apoglyx Akiebolag (AB), Lund, Sweden

A Correction on
RG100204, a novel Aquaporin-9 inhibitor, reduces septic cardiomyopathy and multiple organ failure in murine sepsis

By Mohammad S, O’Riordan CE, Verra C, Aimaretti E, Alves GF, Dreisch K, Evenäs J, Gena P, Tesse A, Rützler M, Collino M, Calamita G and Thiemermann C (2022) Front. Immunol. 13:900906. doi: 10.3389/fimmu.2022.900906

There was an error in Figure 13 as published. The representative images related to Panel A have been inadvertently duplicated in Panel E. The corrected Figure 13 and its caption appear below.

Figure 13
Western blot analysis with bar graphs displays protein expression in five panels labeled A to E. Each panel presents protein bands for phosphorylation and total forms with corresponding graphs. Conditions are Sham with vehicle, CLP with vehicle, and CLP with RG100204 at 1 hour and 8 hours. Significant differences are indicated by asterisks. Panel A shows IKKα/β; B shows IκBα; C shows NF-κB; D shows NLRP3; E shows Cleaved Caspase-1, each quantified in optical density (O.D.) against Sham.

Figure 13. Effect of post-treatment (therapeutic administration) with RG100204 on the NF-ĸB signalling pathway and the activation NLRP3 inflammasome in the heart. Heart samples were collected at the end of the experiment and the NF-kB signalling pathway, as well as the activation of the NLRP3 inflammasome. Densitometry analysis of the bands is expressed as relative optical density (O.D.) of the (A) phosphorylation of IKKa/b at Ser178/180 corrected for the corresponding total IKKa/b content and normalized using the related sham band; (B) phosphorylation of IĸBa at Ser32/36 corrected for the corresponding total IĸBa content and normalized using the related sham band; (C) NF-ĸB p65 subunit levels in both, cytosolic and nuclear fractions expressed as a nucleus/cytosol ratio normalized using the related sham bands; (D) NLRP3 activation, corrected against tubulin and normalized using the related sham bands; and (E) proteolytic cleavage of pro-caspase-1 to activated caspase-1 and normalized using the related sham band. The following groups were studied: sham + vehicle (n = 5), CLP + vehicle (n = 10), CLP +RG100204 (1 h & 8 h) (n = 10). All data were analyzed by one-way ANOVA, followed by a Bonferroni’s post-hoc test. Data are expressed as mean ± SEM. **P < 0.01 and ****P < 0.0001 vs. the respective sham-operated group.

The original article has been updated.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Keywords: aquaporin (AQP), sepsis, cecal ligation and puncture, inflammation, multiple organ failure

Citation: Mohammad S, O’Riordan CE, Verra C, Aimaretti E, Alves GF, Dreisch K, Evenäs J, Gena P, Tesse A, Rützler M, Collino M, Calamita G and Thiemermann C (2025) Correction: RG100204, a novel Aquaporin-9 inhibitor, reduces septic cardiomyopathy and multiple organ failure in murine sepsis. Front. Immunol. 16:1672460. doi: 10.3389/fimmu.2025.1672460

Received: 24 July 2025; Accepted: 08 August 2025;
Published: 21 August 2025.

Edited and reviewed by:

Manuela Mengozzi, Brighton and Sussex Medical School, United Kingdom

Copyright © 2025 Mohammad, O’Riordan, Verra, Aimaretti, Alves, Dreisch, Evenäs, Gena, Tesse, Rützler, Collino, Calamita and Thiemermann. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Shireen Mohammad, cy5tb2hhbW1hZEBxbXVsLmFjLnVr; Christoph Thiemermann, Yy50aGllbWVybWFubkBxbXVsLmFjLnVr

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.