ORIGINAL RESEARCH article
Front. Immunol.
Sec. Vaccines and Molecular Therapeutics
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1675212
This article is part of the Research TopicAdvancing Tissue Repair: Immunomodulatory Bioactive Hydrogels and Immune Cell InteractionsView all 5 articles
Modified recombinant collagen-peptide (RHC)/gallic acid grafted chitosan (CSGA) composites with antibacterial and antioxidant property for wound dressing: A preliminary study
Provisionally accepted
Chen Yu1
Wen Wenjie1Wang Jie1Huang Shiting1Ren Qianqian1Cai Jiayao1
Songlin Zhou1Zhu Chuanding2Xu Lin2Li Rui1Ren Dandan1Peng Liaotian1
CHAO DENG1
Zhang Jue1*- 1Wannan Medical College, Wuhu, China
- 2Docon Stomatological Hospital, Anqing, China
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Abstract :Chronic wounds pose a persistent clinical challenge, primarily due to prolonged bacterial infections. The development of natural antibacterial dressings offers a promising strategy for their effective management. In this study, recombinant human collagen methacrylamide (RHCMA) and gallic acid-grafted chitosan (CSGA) were synthesized and subsequently crosslinked via UV irradiation to form a composite hydrogel (RHCMA-CSGA). The composition and structure of the hydrogel were systematically characterized. Its cytocompatibility and antibacterial properties were also evaluated. The results demonstrated that the hydrogel exhibited excellent biocompatibility and strong antibacterial activity. These findings suggest that the RHCMA-CSGA hydrogel holds great potential as a therapeutic dressing for chronic wound healing.
Keywords: recombinant collagen-peptide, Antibacterial property, wound repair, RHC based hydrogel, Antioxidants
Received: 29 Jul 2025; Accepted: 25 Aug 2025.
Copyright: © 2025 Yu, Wenjie, Jie, Shiting, Qianqian, Jiayao, Zhou, Chuanding, Lin, Rui, Dandan, Liaotian, DENG and Jue. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhang Jue, Wannan Medical College, Wuhu, China
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