REVIEW article
Front. Immunol.
Sec. Cytokines and Soluble Mediators in Immunity
The role of interleukins in peripheral nerve injury and the current status of treatment
Provisionally accepted
- 1辽宁省肿瘤医院, 沈阳市, China
- 2cancer hospital of china medical university, shenyang, China
- 3Cancer Hospital of Dalian University of Technology, shenyang, China
- 4Liaoning University of Traditional Chinese Medicine, Shenyang, China
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Abstract: Peripheral Nerve Injury (PNI) is a common condition in modern clinical practice, characterized by a high incidence and significant debilitating consequences. This narrative review systematically delineates the dual functions of key pro-inflammatory (e.g., IL-1β, IL-6, IL-17) and anti-inflammatory (e.g., IL-4, IL-10, IL-13) interleukins in the spatiotemporal context of nerve injury. This is a narrative review, the review systematically summarizes the dual pro-inflammatory and anti-inflammatory roles of interleukins in peripheral nerve injury. The therapeutic potential of interleukin-based treatment strategies, including inhibitors, agonists, and their combined applications with cell therapy, gene therapy, physical therapy, etc., was explored, and the limitations of current research and future research directions were pointed out. By synthesizing current evidence, this review aims to provide a comprehensive mechanistic overview and highlight emerging interleukin-centric therapeutic paradigms for PNI.
Keywords: interleukin, peripheral nerve injury, cell therapy, Physical Therapy, Gene Therapy
Received: 27 Aug 2025; Accepted: 01 Dec 2025.
Copyright: © 2025 沈, Mingzhu, 金, 喻, 刘, Yao, Jiang, 付 and Li李. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Li Mingzhu
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