REVIEW article
Front. Immunol.
Sec. Multiple Sclerosis and Neuroimmunology
Brain TRPV1 Channel-Mediated Calcium Influx: The Immunomodulatory Pathway of Acupuncture in Neuroinflammation
Provisionally accepted
Qingqing Tang1
Min He1
Peng Zheng2
Mengmeng Sun1
Jiazhen Cao1
Qi Zhang3
Jing He1Run Sun1
Bing Zhu4*
Tie Li1*- 1Changchun University of Chinese Medicine, Changchun, China
- 2The Third Affiliated Clinical Hospital of Changchun University of Chinese Medicine, Changchun, China
- 3Hubei University of Chinese Medicine, Wuhan, China
- 4China Academy of Chinese Medical Sciences, Beijing, China
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Neuroinflammation represents the central pathological process in neurological disorders. Effectively regulating neuroinflammation to restore immune homeostasis and alleviate neuronal damage has emerged as a critical strategy in the prevention and treatment of these diseases. In recent years, the role of acupuncture in neuroimmune regulation, along with its anti-inflammatory and analgesic effects, has attracted considerable attention. Its potential to modulate immune homeostasis and inflammatory responses through various targets and pathways has been gradually elucidated, offering new research directions for the regulation of neuroinflammation. A series of studies have emphasized that acupuncture has significant clinical applications by regulating the immunoinflammatory pathway mediated by the brain's TRPV1 channel. This discovery not only enhances the scientific understanding of the mechanisms underlying acupuncture but also offers new potential targets for the prevention and treatment of neuroinflammation-related diseases. The immunomodulatory properties of brain TRPV1 channels in inflammation associated with the nervous system have been emphasized. Furthermore, this study explores the immunomodulatory benefits of acupuncture in treating neuroinflammation, focusing on the potential mechanisms of TRPV1 channels at the brain level, as well as the criteria for selecting acupoints, intensity, frequency, and other relevant parameters in these studies. A deeper understanding of the neuroimmune regulatory mechanisms mediated by brain
Keywords: braindysfunction, Immunoregulation, Microglia, Neuroinflammation, TRPV1 channel
Received: 06 Sep 2025; Accepted: 29 Nov 2025.
Copyright: © 2025 Tang, He, Zheng, Sun, Cao, Zhang, He, Sun, Zhu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bing Zhu
Tie Li
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