REVIEW article
Front. Immunol.
Sec. Inflammation
PANoptosis: a potential target of cardiomyopathy
Provisionally accepted
- 1Shenyang Sport University, Shenyang, China
- 2China Medical University, Shenyang, China
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Cardiomyopathy is a group of heterogeneous myocardial diseases that seriously threaten patients. Because the underlying molecular pathogenesis of cardiomyopathy is still unclear, treatment options are still limited to palliative drug therapy. Hence, unraveling the molecular pathways that drive the onset and progression of cardiomyopathy is crucial for identifying effective therapeutic targets and devising clinical intervention strategies. Programmed cell death (PCD) is a type of cell death mediated by specific molecular pathways and genetically regulated, among which pyroptosis, apoptosis, and necroptosis are the main forms. Recently, researchers have uncovered that the intricate interplay among various forms of PCD has given rise to the concept of "PANoptosis," which represents an integrated cell death process. Recent studies have found that PANoptosis is a key mediator of cardiomyopathy and is expected to become a potential therapeutic target for improving the prognosis of this disease. This review aims to summarize the current progress in understanding the association between PANoptotic activation and cardiomyopathy, and to explore new therapeutic targets and strategies for treating cardiomyopathy.
Keywords: cardiomyopathy, PANoptosis, PANoptosome, programmed cell death, Potential target
Received: 13 Sep 2025; Accepted: 29 Nov 2025.
Copyright: © 2025 Sun, Lu, Wei, Gao and Dong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mingli Sun
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