REVIEW article
Front. Immunol.
Sec. Inflammation
This article is part of the Research TopicUnderstanding Chronic Inflammation: Mechanisms Behind its PersistenceView all 10 articles
Targeting Persistently Activated Inflammatory Microenvironment to Promote Chronic Wound Healing
Provisionally accepted
Yuxuan Dai1
Yu Chen2*- 1Beilun District People's Hospital of Ningbo, Ningbo, China
- 2The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
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The immune system plays a pivotal role in maintaining the balance of inflammatory responses and facilitating tissue repair and wound healing. However, under the combined influence of immune microenvironmental factors and external stimuli, immune cell dysfunction can lead to persistent activation of the inflammatory milieu, resulting in delayed or impaired wound healing. Therefore, regulating immune responses within the chronic inflammatory microenvironment and suppressing aberrant immune cell activation not only helps restore immune homeostasis but also effectively accelerates the wound healing process. Identifying and modulating novel targets associated with macrophage and T-cell dysregulation, as well as the crosstalk among immune cells, offers new insights and therapeutic strategies for the treatment of chronic inflammation-related disorders and wound repair. This review focuses on the molecular mechanisms underlying aberrant macrophage and T-cell activation, the intercellular crosstalk within the immune microenvironment, and their impact on the wound healing process. Furthermore, it highlights potential therapeutic targets for limiting persistent inflammation and re-establishing immune homeostasis. Elucidating these mechanisms and targets may provide promising avenues for the treatment of chronic inflammatory diseases and for advancing strategies in tissue repair and regeneration.
Keywords: tissue repair, Delayed Healing Wounds, Macrophages, Inflammation, Immunoregulation
Received: 18 Sep 2025; Accepted: 30 Nov 2025.
Copyright: © 2025 Dai and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yu Chen
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