MINI REVIEW article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders
Beyond the Joints: Mechanistic Insights and Multidisciplinary Strategies for Spondyloarthritis-Associated Uveitis
Provisionally accepted
- 1Chengdu Fifth People's Hospital, Chengdu, China
- 2Chengdu Fifth People's Hospital Department of Ultrasound Medicine, Chengdu, China
- 3Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China
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Abstract: Spondyloarthritis (SpA) is a group of diseases characterized by chronic inflammation and extra-articular involvement of tissues and organs. Acute anterior uveitis (AAU), the most common extra-articular manifestation of SpA, typically presents as a unilateral acute disruption of the blood-aqueous barrier, characterized by photophobia, redness of the eye, pain, and blurred vision. The underlying pathogenesis is not fully understood but is thought to involve genetic factors, gut microbiota, and dysregulation of the immune system. Corticosteroids remain the cornerstone of AAU treatment. However, alternative therapies such as nonsteroidal anti-inflammatory drugs (NSAIDs), disease modifying antirheumatic drugs (DMARDs), and biologics have also demonstrated utility. In recent years, biologics have gained increasing attention due to their efficacy and safety. This review summarizes recent research findings and advancements in the diagnosis and management of spondyloarthritis-associated uveitis.
Keywords: Spondyloarthritis, Uveitis, HLA-B27, Extra articular manifestations, biologics
Received: 28 Sep 2025; Accepted: 14 Nov 2025.
Copyright: © 2025 Shuyue, Xiang, Cao, Zhi and Cheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Rui-Juan Cheng, orange411@qq.com
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