MINI REVIEW article
Front. Immunol.
Sec. Inflammation
Mast cells in the bone marrow microenvironment
Provisionally accepted
- University of Bari Aldo Moro, Bari, Italy
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Abstract. The bone marrow microenvironment provides the necessary signals for the development from hematopoietic stem cells into mast cell precursors. Once released in the bloodstream, mast cells quickly migrate to peripheral tissues where they complete their differentiation. Mast cells are located at the interface with the external environment, therefore are among the first cell types that can get in contact with pathogens. Mast cells are found in every tissue, most abundantly near barriers where they exert the role of immune sentinels during both acute and chronic inflammation. Mast cells are known for their effects when eliciting immediate hypersensitivity reactions. However, they are involved in numerous other physiological and pathological conditions such as those that occur in bone marrow microenvironment, as has been discussed in this article.
Keywords: Angiogenesis, Bone Marrow, Fibrosis, Mast Cells, tumor progression
Received: 03 Nov 2025; Accepted: 28 Nov 2025.
Copyright: © 2025 RIBATTI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Domenico RIBATTI
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.