REVIEW article
Front. Immunol.
Sec. Microbial Immunology
This article is part of the Research TopicAdvances in Immunity and Microbiome: Exploring Key Interactions and InnovationsView all 24 articles
Advances in the Study of Gut Microecology and Mechanisms of Hyperuricemia and Gouty Arthritis
Provisionally accepted
Youliang Zhang1
Hengyu Zhang1Tianwen Miao1Xuetao Wang1Yanan Zuo1Renwei Zhang1Liangtong Zhang1Yuan Cheng1Dong Liu2Xin Chen1,3Longcan Li1Xingwen Xie1,3*
Ning Li1,3*- 1Gansu University of Chinese Medicine, Lanzhou, China
- 2Sichuan Province Orthopedic Hospital, Chengdu, China
- 3Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, China
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Gouty arthritis is a metabolic disorder caused by purine metabolism dysregulation, characterized by monosodium urate crystal deposition in and around joints, triggering acute articular inflammation via NLRP3 inflam-masome activation and IL-1β-mediated inflammatory cascades. While hyperuricemia represents a critical biochemical prerequisite for gouty arthritis development, elevated serum urate levels do not invariably lead to the disease. Mounting evidence suggests a significant relationship between gut microbiota and the pathogenesis of both gouty arthritis and hyperuricemia. The gut microbial ecosystem influences host health through metabolic and immune function modulation, performing essential roles in digestion, energy harvesting, and short-chain fatty acid production. Intestinal dysbiosis can damage epithelial integrity, compromise immune tolerance, and activate immune cells, thus contributing to disease onset and progression. Elucidating the complex interactions between gut microbiota and the mechanisms underlying gouty arthritis and hyperuricemia presents promising opportunities for developing novel preventative and therapeutic interventions. This review synthesizes recent advances in understanding the gut-joint axis and evaluates emerging therapeutic strategies including probiotics, dietary interventions, and fecal microbiota transplantation.
Keywords: Gouty arthritis, Gut microbes, Gut Microbiota, intestinal barrier, Novel therapeutic perspectives
Received: 03 Nov 2025; Accepted: 05 Dec 2025.
Copyright: © 2025 Zhang, Zhang, Miao, Wang, Zuo, Zhang, Zhang, Cheng, Liu, Chen, Li, Xie and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xingwen Xie
Ning Li
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