REVIEW article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
This article is part of the Research TopicImmune regulatory networks in the skin during normal and aberrant immunological responses: mechanisms, modulation, and therapeutic targetsView all 8 articles
Mendelian Randomization Studies in Atopic Dermatitis: Causal Insights Across Omics Layers
Provisionally accepted
- 1Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
- 2Department of Allergology and Clinical Immunology, ‘Dr. Carol Davila’ Clinical Nephrology Hospital, Bucharest, Romania
- 3Genomics Research and Development Institute, Bucharest, Romania
- 4Viron Molecular Medicine Institute, Boston, United States
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Atopic dermatitis (AD) is a chronic inflammatory skin disease, shaped by genetic, immune and environmental factors. Even though this complex interaction has been thoroughly studied, uncovering causal relationships between specific exposures and AD remains challenging. Mendelian randomization (MR) has emerged as a powerful tool for establishing causal inferences between exposures and outcomes, using genome-wide association data. MR studies have provided evidence for potential causal associations between AD and a broad spectrum of traits and comorbidities, including neuropsychiatric, cardiometabolic, oncologic, immune-mediated conditions, as well as ophthalmologic and infectious complications. Moreover, multi-omic MR approaches have enabled biomarker and therapeutic target discovery, highlighting opportunities for screening refinement, drug repurposing, and precision medicine. By integrating causal inference tools within multiple omics layers, MR is reshaping our understanding of AD, accelerating progress toward precision medicine in immune-mediated diseases.
Keywords: atopic dermatitis, Genomics, GWAS, Mendelian randomization, Metabolomics, multi-omics, Proteomics
Received: 02 Oct 2025; Accepted: 10 Feb 2026.
Copyright: © 2026 Chera, Bucur and Bumbacea. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Octavian Bucur
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