REVIEW article
Front. Immunol.
Sec. Parasite Immunology
This article is part of the Research TopicInflammation and immune modulation induced by parasitic infectionView all 4 articles
Leishmania mediated regulation of Host metabolism: Impact on host immunity
Provisionally accepted
Somtochukwu S Onwah1
Gaurav Gupta1*
Romaniya Zayats1
Amol Singh Banga2Kashish Chottaria2Gurtej Walia2
JUDE EZEH UZONNA1*- 1IMMUNOLOGY, Department of Immunology, Max Rady College of Medicine ,University of Manitoba, Winnipeg, MB, Canada
- 2NIIT University, Jaipur, India
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ABSTRACT Leishmaniasis, a vector-borne disease affecting millions worldwide, is caused by protozoan parasite Leishmania. In mammalian hosts, Leishmania survives in the hostile environment of macrophages by exploiting key metabolic pathways to evade their destruction and subvert the host immune responses. Understanding of how Leishmania alters host immune cell metabolism could reveal novel targets for vaccines and therapeutics for effective control of Leishmaniasis. This review focuses on Leishmania-induced modulation of host immune response, with particular focus on reprograming of key metabolic pathways in macrophages, dendritic cells, T cells and other immune cells.
Keywords: host parasite, immune cells, immune response, Leishmania, Metabolism
Received: 20 Nov 2025; Accepted: 30 Jan 2026.
Copyright: © 2026 Onwah, Gupta, Zayats, Banga, Chottaria, Walia and UZONNA. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Gaurav Gupta
JUDE EZEH UZONNA
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