CASE REPORT article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Eosinophilic Granulomatosis with Polyangiitis Coexisting with Multiple Myeloma: Independent Entities or Coexistence? A Case Report
Provisionally accepted
- 1Affiliated Hospital of Guizhou Medical University, Guiyang, China
- 2Guizhou Provincial People's Hospital，Guiyang, China., Guiyang, China
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Eosinophilic granulomatosis with polyangiitis (EGPA) represents a systemic necrotizing vasculitis characterized by prominent peripheral eosinophilia. Concomitant plasma cell dyscrasias in the context of EGPA remain exceedingly rare in clinical literature. This paper presents a case of a 49-year-old female patient with recurrent diarrhea, rash, fever, and wheezing. The patient was initially diagnosed with multiple myeloma (MM) due to significant elevation of M protein and immature plasma cells in the bone marrow. However, chemotherapy failed to alleviate her condition, while standardized EGPA treatment achieved disease control. This case of EGPA with clinical manifestations of MM prompts us to consider whether the clinical presentation should follow Occam's razor or Hickam's dictum. Ultimately, we hypothesize that EGPA-induced eosinophil (EOS) perturbs the bone marrow hematopoietic niche. Through the Th2-mediated cytokine milieu, this microenvironment may trigger a reactive, "pseudo-malignant"expansion of plasma cells.
Keywords: eosinophil, Eosinophilic granulomatosis with polyangiitis, Mepolizumab, Multiple Myeloma, plasmacell neoplasm
Received: 22 Nov 2025; Accepted: 12 Feb 2026.
Copyright: © 2026 Qin, Yin, Wu, Zhang, li, Liu, Huang, Cao and Zeng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Longyan Qin
Jiashun Zeng
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