CASE REPORT article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Radiotherapy Combined with Immunotherapy Achieves Clinical Complete Response in Elderly Metastatic Penile Cancer : a case report
Guizhen Huang
Yanghui Li
Su Li
Long Gong
Hongtao Chen
Xianming Li
Guixiang Liao
Shenzhen People's Hospital, Jinan University, Shenzhen, China
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Abstract
Background: A combination of local and systemic therapies is used to treat inguinal lymph node metastases post-penile cancer surgery. This multimodal approach may include surgery, chemotherapy, radiotherapy, and immunotherapy. Case summary: We describe an 89-year-old male with a history of penile cancer status post resection, who presented with multiple metastases to the left inguinal lymph nodes confirmed by pathological biopsy. The patient was treated with a combination of radiotherapy and Pembrolizumab. Following this combined modality therapy, he experienced symptomatic relief and achieved a progression-free survival exceeding 38 months. Conclusion: This case suggests that concurrent radiotherapy plus Pembrolizumab may achieve durable remission in elderly, chemotherapy-intolerant, metastatic PSCC, but verification in more patients is needed.
Summary
Keywords
Immune checkpoint inhibitor, inguinal lymph nodes, penile squamous cell carcinoma, Radiotherapy, Survival
Received
08 January 2026
Accepted
20 February 2026
Copyright
© 2026 Huang, Li, Li, Gong, Chen, Li and Liao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Guixiang Liao
Disclaimer
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