Frontiers in Immunology | Immunological Tolerance and Regulation

Review

Published on 19 Dec 2025

Modular mastery of inflammation: umbilical cord mesenchymal stem cells as a therapeutic frontier

in Immunological Tolerance and Regulation

Li Yin
Chen-yang Sun
Gui-lai Chen
Zhuo Xiang
Bao-quan Hu
Fang Zhou
Qiang Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1721947

238 views

Original Research

Published on 16 Dec 2025

Immunogenicity of a CXCL8-based biopharmaceutical drug candidate in comparison to its wildtype form

in Immunological Tolerance and Regulation

Elisa Talker
Tanja Gerlza
Philippe Stas
Christina Trojacher
Tiziana Adage
Andreas J. Kungl

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679409

305 views

Original Research

Accepted on 12 Dec 2025

Decidual stromal cells drive CD16+ macrophages towards an immunoregulatory phenotype via extracellular matrix-adhesion molecule interaction during early pregnancy

in Immunological Tolerance and Regulation

Hui-Li Yang
Jia-Wei Shi
Zhen-Zhen Lai
Xin Li
Chun-Jie Gu
Zi-Meng Zheng
Hong-Bo Zhao
Jiang-Feng Ye
Li Wang
Ting Peng

Frontiers in Immunology

189 views

Brief Research Report

Accepted on 12 Dec 2025

Pazopanib-associated remodeling of platelet-immune cell crosstalk and immune suppressive platelet-derived extracellular vesicles in metastatic RCC

in Immunological Tolerance and Regulation

Gianpiero Lupoli
Jeannette Salsetta
Stefano Bergamini
Alessandro Mereu
Agata Cova
Elisa D'Angelo
Eriomina Shahaj
Elisabetta Vergani
Licia Rivoltini
Elena Verzoni

Frontiers in Immunology

152 views

Original Research

Accepted on 11 Dec 2025

Identification and Validation of an Endotoxin Tolerance–Based Prognostic Model with Therapeutic Insights in Sepsis

in Immunological Tolerance and Regulation

Yu Xie
Yadong Su
Yin Qin
Qiuhong Zhang
Jie Liu
Yanglin Wu
Ning Du
Yu Jiang
Gang Liu

Frontiers in Immunology

182 views

Original Research

Published on 11 Dec 2025

Macrophage activation of the TREM2-DAP12-SYK pathway shapes the adipose tissue microenvironment in obesity and unveils the therapeutic potential of natural compounds egcg and SMRR

in Immunological Tolerance and Regulation

Wang Luoying
Yi Xingcheng
Cong Donghang
Long Mengtuan
Wang Ping
Zhang Lijuan
Li Yupeng
Zhao Tianyi
Chen Hongyu
Wang Song

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694985

824 views

Mini Review

Published on 09 Dec 2025

Harnessing the immunomodulatory properties of HLA-G for advanced immunotherapies

in Immunological Tolerance and Regulation

Xeni Beli
Nikolaos Savvopoulos
Dionysia Kefala
Memnon Lysandrou
Maria Liga
Alexandros Spyridonidis

Frontiers in Immunology

doi 10.3389/fimmu.2025.1716778

563 views

Perspective

Accepted on 08 Dec 2025

Considerations for biologics as front-line treatment in allergic diseases

in Immunological Tolerance and Regulation

Akash Kothari
Lisa Hung
Julia Upton

Frontiers in Immunology

273 views

Original Research

Published on 08 Dec 2025

Immunogenicity risk assessment of peptide-related impurities identified in generic teriparatide products

in Immunological Tolerance and Regulation

Aimee E. Mattei
Brian J. Roberts
Sandra Lelias
Shah Miah
Kristina E. Howard
James L. Weaver
Daniela Verthelyi
Eric S. Pang
Katie Edwards
Anne S. De Groot

Frontiers in Immunology

doi 10.3389/fimmu.2025.1730346

1,383 views

Original Research

Published on 08 Dec 2025

WNT16 from decidual stromal cells orchestrates M2 macrophage polarization via β-catenin signaling and chromatin remodeling at the maternal-fetal interface

in Immunological Tolerance and Regulation

Lingyu Chang
Jiani Guo
Xi Xue
Yang Yan
Xinyi Li
Weijie Zhao
Xiaoli Sun
Jiajia Chen
Meirong Du

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712898

542 views

Original Research

Published on 05 Dec 2025

Pig regulatory macrophages as a donor-derived immune modulators in xenotransplantation

in Immunological Tolerance and Regulation

Phu Chi Vu
Nhat Minh Dang
Vinh Phuoc Nguyen
Jonghyeok Jung
Joohyun Shim
Jeong Ho Hwang
Thi Xoan Hoang
Ik Jin Yun
Jae Young Kim

Frontiers in Immunology

doi 10.3389/fimmu.2025.1718937

660 views

Original Research

Accepted on 04 Dec 2025

Xuanqing Hefa formula relieves sepsis-triggered acute lung injury by targeting the NLRP3/Caspase-1 pyroptosis mechanism

in Immunological Tolerance and Regulation

Can Lei
Chunxia Zhao
Xucheng Li
Kangli Wang
Tianfen Cen
Qingquan Liu
Xiaolong Xu
Jun Zhang

Frontiers in Immunology

175 views

Original Research

Published on 04 Dec 2025

Immunophenotyping of septic shock patients with endotheliopathy: focus on monocyte subtypes and Immune regulatory molecules

in Immunological Tolerance and Regulation

Saif Al-Haidar
Martin Schønemann-Lund
Mikkel Gybel-Brask
Jakob Stensballe
Lars Andresen
Pär I. Johansson
Morten H. Bestle
Søren Skov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656815

526 views

Original Research

Published on 01 Dec 2025

Immune dysregulation in preeclampsia: integrative analysis of peripheral transcriptomes and placental single-cell land-scapes

in Immunological Tolerance and Regulation

Shu Zheng
Peng Xu
Huimin Shen
Chang Shu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1638603

806 views

Original Research

Accepted on 29 Nov 2025

Cigarette Smoke Exposure Triggers Dendritic Cell-Derived Exosome-Mediated Th17 and Treg Polarization through an Autophagy-and Necroptosis-Associated SIRT1-Dependent Mechanism

in Immunological Tolerance and Regulation

Dongling Luo
Jifeng Liu
Leilei Ya
Chengxuan Ruan
Siyi Ou
Yiqian Wei
Qingyun Lin
Zhaohong Huang
Kaiwen Nong

Frontiers in Immunology

439 views

Systematic Review

Accepted on 28 Nov 2025

Insights into immunogenicity and therapeutic strategies to mitigate the immune response in infantile-onset Pompe disease: A comprehensive systematic literature review

in Immunological Tolerance and Regulation

Priya Kishnani
JMP Van Den Hout
Andreas Hahn
David Kronn
Yin-Hsiu Chien
Mei Han
Jennifer Heuterman
Susan Sparks
Colin Glen
Nadia Daba

Frontiers in Immunology

172 views

Original Research

Accepted on 27 Nov 2025

Human tolerogenic dendritic cell subtypes exert divergent effects on induction of cytotoxic CD4+ T cells

in Immunological Tolerance and Regulation

Gabrielle Barran
Najib Namaane
Abdul Mannan Baru
Amy Elizabeth Anderson
Jane Falconer
Catharien Maria Ursula Hilkens

Frontiers in Immunology

264 views

Review

Published on 27 Nov 2025

Macrophage-tregs crosstalk: the “hub” of the immune network in MASLD

in Immunological Tolerance and Regulation

Huihui Zhao
Weili Wang
Pengchao Zhu
Zhaohong Shi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680878

1,081 views

Review

Published on 27 Nov 2025

Breach and restoration of retinal immune privilege: barrier failure, innate dysregulation, and adaptive autoimmunity

in Immunological Tolerance and Regulation

Qiwei Fan
Zhijie Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1703382

860 views

Review

Published on 25 Nov 2025

Dual signaling cascade regulating gut-lung axis in Interleukin-6/Interleukin-17 for NSCLC immuno pathogenesis

in Immunological Tolerance and Regulation

Riya Khilwani
Shailza Singh

Frontiers in Immunology

doi 10.3389/fimmu.2025.1649517

1,063 views

Original Research

Published on 25 Nov 2025

Multiple tail vein injections of adipose-derived mesenchymal stem cells ameliorate allergic rhinitis in mice: superior efficacy of prolonged regimens

in Immunological Tolerance and Regulation

Yutong Xie
Jiacheng Zhang
Wenhan Yang
Zhiyu Pan
Lian Wang
Ju Lai
Kai Fan
Yalei Dai
Keqiang Zuo
Fei He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1678927

949 views

Original Research

Published on 19 Nov 2025

The recombinant IL-35 and anti-Ebi3 antibody administration before implantation modulate immune regulation and fetal outcomes in an abortion-prone mouse model

in Immunological Tolerance and Regulation

Anna Slawek
Paulina Kubik
Mateusz Psurski
Anna Ewa Kedzierska
Anna Chelmonska-Soyta

Frontiers in Immunology

doi 10.3389/fimmu.2025.1648641

1,319 views

Original Research

Published on 18 Nov 2025

Ursolic acid induces colorectal cancer cells ferroptosis via regulation of system xc- and miR-214-3p/Stat3/GPX4 axis

in Immunological Tolerance and Regulation

Yao Shi
Changju Ma
Xiaojuan Tang
Haojie Su
Yue Lu
Jianan Wei
Li Li
Tianhua Huang
Xicheng Wang
Xintian Qin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1674321

1,259 views

Review

Published on 17 Nov 2025

The past, present, and future of anti-idiotype antibodies

in Immunological Tolerance and Regulation

William J. Murphy
Craig P. Collins
Heinz Kohler

Frontiers in Immunology

doi 10.3389/fimmu.2025.1686107

1,047 views

1,634 articles

articles

Modular mastery of inflammation: umbilical cord mesenchymal stem cells as a therapeutic frontier

Immunogenicity of a CXCL8-based biopharmaceutical drug candidate in comparison to its wildtype form

Decidual stromal cells drive CD16+ macrophages towards an immunoregulatory phenotype via extracellular matrix-adhesion molecule interaction during early pregnancy

Pazopanib-associated remodeling of platelet-immune cell crosstalk and immune suppressive platelet-derived extracellular vesicles in metastatic RCC

Identification and Validation of an Endotoxin Tolerance–Based Prognostic Model with Therapeutic Insights in Sepsis

Macrophage activation of the TREM2-DAP12-SYK pathway shapes the adipose tissue microenvironment in obesity and unveils the therapeutic potential of natural compounds egcg and SMRR

Harnessing the immunomodulatory properties of HLA-G for advanced immunotherapies

Considerations for biologics as front-line treatment in allergic diseases

Immunogenicity risk assessment of peptide-related impurities identified in generic teriparatide products

WNT16 from decidual stromal cells orchestrates M2 macrophage polarization via β-catenin signaling and chromatin remodeling at the maternal-fetal interface

Pig regulatory macrophages as a donor-derived immune modulators in xenotransplantation

Xuanqing Hefa formula relieves sepsis-triggered acute lung injury by targeting the NLRP3/Caspase-1 pyroptosis mechanism

Immunophenotyping of septic shock patients with endotheliopathy: focus on monocyte subtypes and Immune regulatory molecules

Immune dysregulation in preeclampsia: integrative analysis of peripheral transcriptomes and placental single-cell land-scapes

Cigarette Smoke Exposure Triggers Dendritic Cell-Derived Exosome-Mediated Th17 and Treg Polarization through an Autophagy-and Necroptosis-Associated SIRT1-Dependent Mechanism

Insights into immunogenicity and therapeutic strategies to mitigate the immune response in infantile-onset Pompe disease: A comprehensive systematic literature review

Human tolerogenic dendritic cell subtypes exert divergent effects on induction of cytotoxic CD4+ T cells

Macrophage-tregs crosstalk: the “hub” of the immune network in MASLD

Breach and restoration of retinal immune privilege: barrier failure, innate dysregulation, and adaptive autoimmunity

Dual signaling cascade regulating gut-lung axis in Interleukin-6/Interleukin-17 for NSCLC immuno pathogenesis

Multiple tail vein injections of adipose-derived mesenchymal stem cells ameliorate allergic rhinitis in mice: superior efficacy of prolonged regimens

The recombinant IL-35 and anti-Ebi3 antibody administration before implantation modulate immune regulation and fetal outcomes in an abortion-prone mouse model

Ursolic acid induces colorectal cancer cells ferroptosis via regulation of system xc- and miR-214-3p/Stat3/GPX4 axis

The past, present, and future of anti-idiotype antibodies