Frontiers in Immunology | Immunological Tolerance and Regulation

Original Research

Published on 05 Nov 2025

Identification and validation of paraptosis-related biomarkers in recurrent miscarriage

in Immunological Tolerance and Regulation

Yunhui Wan
Fang Fang
Qiao Wang
Jia Xu
Pei Zhu
Ying Cui
Lili Hou
Huimin Wang
Xiaoyong Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656650

417 views

Review

Published on 04 Nov 2025

Genetically modified pigs with α1,3-galactosyltransferase knockout and beyond: a comprehensive review of xenotransplantation strategies

in Immunological Tolerance and Regulation

Ewelina Stelcer
Anna Wozniak
Dorota Magner
Joanna Zeyland

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663246

366 views

Review

Published on 03 Nov 2025

Use of regulatory cells for achieving functional tolerance of pig heart xenotransplants in humans: a literature review

in Immunological Tolerance and Regulation

Gheorghe Traian Braileanu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1648926

460 views

Original Research

Published on 03 Nov 2025

Immune tolerance induction using the thyrotropin receptor epitope 78–94 (p37) prevents Graves’ disease in HLA-DR3 transgenic mice

in Immunological Tolerance and Regulation

Hidefumi Inaba
Itsuki Nonaka
Daiki Hashimoto
Moritoshi Hirono
Shuhei Morita
Hiroaki Kimura
Hiroshi Iwakura
Takashi Akamizu
Masanori Nakata

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633350

437 views

Original Research

Accepted on 31 Oct 2025

Ursolic acid induces colorectal cancer cells ferroptosis via regulation of system xc-and miR-214-3p/Stat3/GPX4 axis

in Immunological Tolerance and Regulation

Yao Shi
Changju Ma
Tang Xiao Juan
Haojie Su
Yue Lu
Jianan Wei
Li Li
Tianhua Huang
Xicheng Wang
Xintian Qin

Frontiers in Immunology

Clinical Trial

Published on 31 Oct 2025

Immunomodulatory effects and mechanisms of Qi-Xu-Tiao-Ti formula in Qi-deficiency constitution: a randomized controlled trial integrated with multi-omics and network pharmacology analysis

in Immunological Tolerance and Regulation

Renyun Cui
Ming Fan
Chengzhi Yang
Cheng Chen
Jinlu Xia
Xi Liu
Guohui Zhang
Fangli Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675502

980 views

Original Research

Accepted on 30 Oct 2025

The recombinant IL-35 and anti-Ebi3 antibody administration before implantation modulate immune regulation and fetal outcomes in an abortion-prone mouse model

in Immunological Tolerance and Regulation

Anna Sławek
Paulina Kubik
Mateusz Psurski
Anna Ewa Kedzierska
Anna Chelmonska-Soyta

Frontiers in Immunology

213 views

Review

Accepted on 30 Oct 2025

The Past, Present, and Future of Anti-Idiotype Antibodies

in Immunological Tolerance and Regulation

William Murphy
Craig P. Collins
Heinz Kohler

Frontiers in Immunology

Original Research

Published on 30 Oct 2025

Proteomic analysis of exosomes from Brucella abortus-infected macrophages reveals possible mechanisms of immune evasion and host modulation

in Immunological Tolerance and Regulation

Francisco Álvarez
Vicente Arriagada
María Jesús Aburto
Ítalo Ferrari
Ilse Alvarado
José Barrales
Roberto Vidal
Felipe del Canto
Leonardo A. Gómez
Ángel A. Oñate

Frontiers in Immunology

doi 10.3389/fimmu.2025.1685245

786 views

Opinion

Published on 30 Oct 2025

If Tregs were people: regulation as the quiet architecture of immunity and society

in Immunological Tolerance and Regulation

Bruno B. Andrade
Mariana Araújo-Pereira

Frontiers in Immunology

doi 10.3389/fimmu.2025.1720091

521 views

Review

Accepted on 29 Oct 2025

Phytochemicals as modulators of dendritic cell functions: implications for tolerogenic cell-based therapy

in Immunological Tolerance and Regulation

Tünde Fekete
Kitti Pázmándi

Frontiers in Immunology

265 views

Editorial

Published on 28 Oct 2025

Editorial: Exploring immunomodulation to balance maladaptive inflammation and restore tissue homeostasis

in Immunological Tolerance and Regulation

David M. Smadja
Maxime Jeljeli
Alexandre G. Lellouch

Frontiers in Immunology

doi 10.3389/fimmu.2025.1723620

501 views

Systematic Review

Published on 27 Oct 2025

Comparing the circulating immune profile of women with and without recurrent implantation failure: a systematic review and meta-analysis

in Immunological Tolerance and Regulation

Daxina Bhatt
Yousef Alebrahim
Abdullah Shahzad
Lamiya Mohiyiddeen
Elizabeth Mann

Frontiers in Immunology

doi 10.3389/fimmu.2025.1627514

508 views

Original Research

Published on 24 Oct 2025

Impaired NLRP3 inflammasome signaling diverts pyroptotic to apoptotic caspase activation in macrophages

in Immunological Tolerance and Regulation

Ying-qing Gan
Yuan-wen Cai
Xiu-wen Liang
Ling-Zhi Wang
Fu-li Shi
Nuo Sun
Ya-ping Li
Rong Xu
Bo Hu
Qing-bing Zha

Frontiers in Immunology

doi 10.3389/fimmu.2025.1631152

677 views

Clinical Trial

Published on 22 Oct 2025

Trends in allergen-reactive CRTH2+ T cells and TARC associated with successful outcomes in a phase 2 cashew oral immunotherapy study

in Immunological Tolerance and Regulation

Sayantani B. Sindher
Andrea Fernandes
Monali Manohar
Shu Cao
Sheena Gupta
Ella Parsons
Dinara Bogetic
Divya Kumar
Jessica Rogers
Julia Thompson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655975

2,002 views

Original Research

Published on 21 Oct 2025

Human leukocyte antigen-G isoform HLA-G2/6, but not HLA-G1/4/5, is an independent indicator of poor survival in patients with colorectal cancer

in Immunological Tolerance and Regulation

Xia Zhang
Qiu-Yue Han
Jian-Gang Zhang
Jiao Lin
Wei-Hua Yan
Aifen Lin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1672144

798 views