Frontiers in Immunology | Immunological Tolerance and Regulation

Review

Published on 17 Jul 2026

Latest advances in nanodrug delivery systems for modulating the immune microenvironment in triple-negative breast cancer

in Immunological Tolerance and Regulation

Xiaoya Dong
Fengxin Cui
Lei Wang
Mai Wu
Yiling Liu
Lehan Gao
Junyao Xie
Xinru Lin
Jianming Sun
Xiaorong Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2026.1793737

300 views

Review

Published on 16 Jul 2026

Tryptophan metabolism in liver transplantation immune tolerance

in Immunological Tolerance and Regulation

Wei Li
Ao Ren

Frontiers in Immunology

doi 10.3389/fimmu.2026.1873690

412 views

Review

Published on 15 Jul 2026

The emerging role of ZDHHC9 in cancer: from protein palmitoylation to tumor progression and immune regulation

in Immunological Tolerance and Regulation

Yi Fu
Ming Ma
Hailong Zhao
Zunyao Xiao

Frontiers in Immunology

doi 10.3389/fimmu.2026.1867145

214 views

Review

Published on 15 Jul 2026

The mechanisms by which free heme exacerbates sepsis and the potential therapeutic targets

in Immunological Tolerance and Regulation

Zheyang Sun
Junjie Cheng
Yuanjie Zhu
Lu Jiang
Min Li

Frontiers in Immunology

doi 10.3389/fimmu.2026.1743737

295 views

Review

Published on 15 Jul 2026

AIRE transcriptional condensates in central tolerance: a multiscale mechanistic perspective

in Immunological Tolerance and Regulation

Jiejie He
Weiwei Xue
Jun Zhang
Yan Li

Frontiers in Immunology

doi 10.3389/fimmu.2026.1859704

342 views

Review

Accepted on 14 Jul 2026

Iron Homeostasis and Macrophage Polarization in Oral Squamous Cell Carcinoma: Mechanisms and Therapeutic Perspectives

in Immunological Tolerance and Regulation

Ahmed Bashah
Eslam Ghaleb
Ali Al-waqeerah
Gang Chen

Frontiers in Immunology

Original Research

Accepted on 14 Jul 2026

Free Epstein-Barr Virus-Induced Gene 3 (EBI3) Functions as an Autonomous Immunosuppressive Cytokine to Maintain Immune Tolerance

in Immunological Tolerance and Regulation

Pingchang Yang
Beiping Miao
Ruishi Zhang
Yanyu Ye
Liguo Li
Pengyuan Zheng
Haoyue Zheng
Gui Yang

Frontiers in Immunology

Case Report

Accepted on 13 Jul 2026

Cascade of Opportunistic Infections in Focal Segmental Glomerulosclerosis Under Dual Immunosuppressive Therapy: A Case Report

in Immunological Tolerance and Regulation

Che-Hsi Wu
Jia-Jung Lee
Daw-Yang Hwang
Chen-Yu Wei
Sheng-Yang Li
Jih-Jin Tsai

Frontiers in Immunology

Review

Accepted on 10 Jul 2026

Circular RNAs in Cervical Cancer: From ceRNA Networks to Epitranscriptomic Regulation, Immune Modulation, and Metastatic Reprogramming

in Immunological Tolerance and Regulation

Heying Huang
Lifeng Liu
Yuemei Cui
Fanchen Zhou
Jing Liu
Qianying Chen
Zhengyan Li
Bing Liu

Frontiers in Immunology

163 views

Editorial

Accepted on 10 Jul 2026

EDITORIAL: METABOLITE-INDUCED METABOLIC REPROGRAMMING IN THE IMMUNE SYSTEM

in Immunological Tolerance and Regulation

Jacqueline Liszeth Oliva-Ramírez
Heriberto Prado-García
Francisco Javier Sánchez-García

Frontiers in Immunology

179 views

Review

Published on 10 Jul 2026

Natural products and immune-cell responses in osteoarthritis: mechanisms, evidence maturity, and translational gaps

in Immunological Tolerance and Regulation

Jinhu Jia
Yi Zhang
Weizheng Wang
Yangfan Qi
Jinliang Gao

Frontiers in Immunology

doi 10.3389/fimmu.2026.1883774

278 views

Original Research

Accepted on 09 Jul 2026

Multi-omics analysis identifies a hepatocyte-associated signature in alcohol-related liver injury

in Immunological Tolerance and Regulation

Ran Ding
Fan Qi
Qianqian Dai
Kangfan Li
Yuan Zhang

Frontiers in Immunology

119 views

Original Research

Published on 09 Jul 2026

Engineering allogeneic type 1 regulatory T cells: a scalable, off-the-shelf platform for restoring immune tolerance

in Immunological Tolerance and Regulation

Molly Javier Uyeda
Audrey Re
Chunyi Tang
Melissa McLaughlin
Daryl Humes
Steven Sexton
Robert Freeborn
Isaura Villalba
Kevin Nugent
James Adams

Frontiers in Immunology

doi 10.3389/fimmu.2026.1848770

1,523 views

Original Research

Accepted on 08 Jul 2026

Defining nature, responses and drivers of regulatory-and conventional CD4+ T cells in the human term decidua

in Immunological Tolerance and Regulation

Jannie Borst
Lotte J. Verleng
Julia Busselaar
Mark Mensink
Ellen Schrama
Hanneke Kapsenberg
Carin Van Der Keur
Xin Lei
Michael Eikmans
Yanling Xiao

Frontiers in Immunology

Systematic Review

Published on 08 Jul 2026

Development and trend of stem cell therapy for diabetes: a comprehensive review based on knowledge visualization

in Immunological Tolerance and Regulation

Xinyu Huang
Qingguang Chen
Hao Lu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1856373

464 views

Case Report

Published on 08 Jul 2026

Case Report: Dupilumab-associated ulcerative colitis: elucidating the pathomechanistic link between Th2 blockade and Th17 polarized intestinal inflammation

in Immunological Tolerance and Regulation

Fanghui Fu
Qing Zhao
Lei Ma
Aili Wang
Zhe Wang
Xiaoyang Xu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1875748

468 views

Perspective

Published on 06 Jul 2026

The immune system as a regulator of normal physiology

in Immunological Tolerance and Regulation

John V. Forrester
Lucia Kuffova
Andrew D. Dick

Frontiers in Immunology

doi 10.3389/fimmu.2026.1867359

939 views

Review

Accepted on 02 Jul 2026

Reprogramming the Wound Microenvironment: Identity Remodeling Strategies for Fibroblasts, Keratinocytes, and Macrophages

in Immunological Tolerance and Regulation

Jing Wang
Min Chen
Jiao Wei
Xiaojun Chen
Chenglong Wang
Huirong Feng

Frontiers in Immunology

163 views

Original Research

Published on 02 Jul 2026

Effects of cassava polysaccharides on gut microbiome, intestinal barrier and macrophage activation

in Immunological Tolerance and Regulation

Houmei Yu
Qingqun Yao
Liming Lin
Chunping Jian
Peixu Du
Jinquan Zhang
Yusi Fang
Mengying Liu
Qinfei Wang
Zhenwen Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1874777

647 views

Original Research

Published on 02 Jul 2026

Development and efficacy of ex vivo expanded autologous regulatory T cells for the treatment of amyotrophic lateral sclerosis

in Immunological Tolerance and Regulation

Ya You
Huifang Zhu
Qian Zhang
Juntao Wang
Chao Dong
Zheng Yang
Jun Zhang
Yushang Zhang
Maoyan Zhang
Mingqi Lu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1854252

822 views

Brief Research Report

Published on 01 Jul 2026

The IL-10-producing NKT10 subset plays a critical role in preventing graft-versus-host-disease

in Immunological Tolerance and Regulation

Abel Trujillo-Ocampo
Drew Boagni
Maison Grefe
Jelita Clinton
Hong He
Ling Yu
Dan Li
Qing Ma
Seon Hee Chang
Jin S. Im

Frontiers in Immunology

doi 10.3389/fimmu.2026.1817755

505 views

Review

Published on 01 Jul 2026

OTU deubiquitinases as immune-circuit editors: from human immunopathology to therapeutic prioritization

in Immunological Tolerance and Regulation

Yi Guo
Yue Song
Chenxin Wang
Rui Xiong
Xinyu Bao
Surui Lu
Wenhan Wu
Xijun Wang
Jiyuan Liao
Yongfen Bao

Frontiers in Immunology

doi 10.3389/fimmu.2026.1843621

545 views

Review

Published on 01 Jul 2026

Regulatory T cells in pregnancy disorders: a multi-dimensional framework for biomarkers and therapeutic strategies

in Immunological Tolerance and Regulation

Ning Zhang
Jun Zhou
Wenxue Ma
Jing Li

Frontiers in Immunology

doi 10.3389/fimmu.2026.1850984

863 views

Systematic Review

Published on 26 Jun 2026

Immune regulation in mitochondrial transfer: knowledge structure and emerging trends from a bibliometric perspective

in Immunological Tolerance and Regulation

Qiyu He
Zhimin Tan
Juan Xu
Tianhong Wang
Qian Li
Xiaoqiang Li

Frontiers in Immunology

doi 10.3389/fimmu.2026.1850600

1,061 views

1,742 articles

articles

Latest advances in nanodrug delivery systems for modulating the immune microenvironment in triple-negative breast cancer

Tryptophan metabolism in liver transplantation immune tolerance

The emerging role of ZDHHC9 in cancer: from protein palmitoylation to tumor progression and immune regulation

The mechanisms by which free heme exacerbates sepsis and the potential therapeutic targets

AIRE transcriptional condensates in central tolerance: a multiscale mechanistic perspective

Iron Homeostasis and Macrophage Polarization in Oral Squamous Cell Carcinoma: Mechanisms and Therapeutic Perspectives

Free Epstein-Barr Virus-Induced Gene 3 (EBI3) Functions as an Autonomous Immunosuppressive Cytokine to Maintain Immune Tolerance

Cascade of Opportunistic Infections in Focal Segmental Glomerulosclerosis Under Dual Immunosuppressive Therapy: A Case Report

Circular RNAs in Cervical Cancer: From ceRNA Networks to Epitranscriptomic Regulation, Immune Modulation, and Metastatic Reprogramming

EDITORIAL: METABOLITE-INDUCED METABOLIC REPROGRAMMING IN THE IMMUNE SYSTEM

Natural products and immune-cell responses in osteoarthritis: mechanisms, evidence maturity, and translational gaps

Multi-omics analysis identifies a hepatocyte-associated signature in alcohol-related liver injury

Engineering allogeneic type 1 regulatory T cells: a scalable, off-the-shelf platform for restoring immune tolerance

Defining nature, responses and drivers of regulatory-and conventional CD4+ T cells in the human term decidua

Development and trend of stem cell therapy for diabetes: a comprehensive review based on knowledge visualization

Case Report: Dupilumab-associated ulcerative colitis: elucidating the pathomechanistic link between Th2 blockade and Th17 polarized intestinal inflammation

The immune system as a regulator of normal physiology

Reprogramming the Wound Microenvironment: Identity Remodeling Strategies for Fibroblasts, Keratinocytes, and Macrophages

Effects of cassava polysaccharides on gut microbiome, intestinal barrier and macrophage activation

Development and efficacy of ex vivo expanded autologous regulatory T cells for the treatment of amyotrophic lateral sclerosis

The IL-10-producing NKT10 subset plays a critical role in preventing graft-versus-host-disease

OTU deubiquitinases as immune-circuit editors: from human immunopathology to therapeutic prioritization

Regulatory T cells in pregnancy disorders: a multi-dimensional framework for biomarkers and therapeutic strategies

Immune regulation in mitochondrial transfer: knowledge structure and emerging trends from a bibliometric perspective