Frontiers in Immunology

Case Report

Accepted on 09 Jan 2026

Targeted interleukin-6 (IL-6) blockade by siltuximab for cytokine release syndrome control and infection limitation in thirteen patients treated with bi-specific T-cell engagers

in Inflammation

JEANFRANCOIS ROSSI
Thierry Cailleux
Emma Wisnewski
Julie Coussirou
Françoise de Crozals

Frontiers in Immunology

159 views

Review

Published on 09 Jan 2026

Exploring cell death mechanisms in liver transplantation: implications for graft survival

in Inflammation

Hirofumi Hirao
Takeshi Watanabe
Yoichiro Uchida
Etsuro Hatano

Frontiers in Immunology

doi 10.3389/fimmu.2025.1700382

1,029 views

Original Research

Published on 09 Jan 2026

Lung epithelial and alveolar macrophage-like cell interactions significantly modify innate responses to bacterial endotoxin with the involvement of direct cellular contacts, TNF-α, ICAM1 and MCP-1

in Inflammation

Connor Wood
Shagun Khera
Minjeong Woo
Vikram Sharma
Justyna Lopatecka
Frederic Coulon
Zaheer Nasir
Vincent Delorme
Simon K. Jackson
György Fejer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715943

1,347 views

Review

Published on 09 Jan 2026

Macrophage polarization in acute myocardial infarction: multidimensional regulation and emerging therapeutic opportunities

in Inflammation

Zilv Ye
Bo Wang
Zhengdong Wan
Jiawei Guo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1710249

990 views

Original Research

Published on 08 Jan 2026

Extracellular CIRP augments inflammation in acute kidney injury via NKG2D-positive macrophages

in Inflammation

Fangming Zhang
Hui Jin
Chuyi Tan
Ping Wang
Max Brenner

Frontiers in Immunology

doi 10.3389/fimmu.2025.1703126

851 views

Original Research

Published on 08 Jan 2026

Assessing the endothelium’s role in COVID-19 severity using the HUVEC model

in Inflammation

Sanzio Silva Santana
Sètondji Cocou Modeste Alexandre Yahouédéhou
Corynne Stéphanie Ahouéfa Adanho
Jéssica Rebouças Silva
Hayna Malta Santos
Cynara Gomes Barbosa
Thassila Nogueira Pitanga
Valéria Matos Borges
Vitor Fortuna
Isa Menezes Lyra

Frontiers in Immunology

doi 10.3389/fimmu.2025.1689772

841 views

Review

Accepted on 07 Jan 2026

Inflammation–Metabolism–Fibrosis Axis: Mechanisms and Therapeutic Strategies Targeting the Chronicity of Pelvic Inflammatory Disease

in Inflammation

Xiange Liu
Caixia zhu
Junjiang li
Li zhang
Wenxiang Yao

Frontiers in Immunology

206 views

Original Research

Published on 07 Jan 2026

Elevated circulating cell-free mitochondrial DNA in fabry disease: insights into inflammatory activation

in Inflammation

Yujing Yuan
Xinyu Zhang
Yawen Zhao
Yikang Wang
Jingyi Huang
Qingqing Wang
Xueqin Song
Jianwen Deng
Zhaoxia Wang
Yun Yuan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1706045

906 views

Original Research

Published on 07 Jan 2026

Farrerol inhibits ferroptosis and protects against LPS-induced acute lung injury by targeting the RUNX1/SLC7A11 axis

in Inflammation

Yueyan Yang
Shihua Deng
Teng Liu
Qing Yin
Min Yang
Xintao Zhang
Zhongyong Jiang
Xiaobian Wang
Sunhan Zhang
Ting Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1720843

984 views

Original Research

Published on 07 Jan 2026

Long-term memory in epithelia: transient IFNγ exposure drives stable repression of TFF1 in gastric epithelial cells via epigenetic changes

in Inflammation

Antonia Voli
Daniela Eletto
Fatima Maria Mentucci
Chiara Centrella
Martina Pannetta
Francesco Boccellato
Alfonso Finizio
Silvana Morello
Caterina Giraulo
Amalia Porta

Frontiers in Immunology

doi 10.3389/fimmu.2025.1731220

927 views

Original Research

Published on 07 Jan 2026

Functional physiological, psychological, and biochemical reactivity to socially evaluated cold pressor test in hereditary angioedema patients (FRoSEn)

in Inflammation

Beatrice De Maria
Luca Ranucci
Clara Gino
Azzurra Cesoni Marcelli
Lorenza Chiara Zingale
Aida Zulueta
Laura Adelaide Dalla Vecchia
Alessandra Gorini
Francesca Perego

Frontiers in Immunology

doi 10.3389/fimmu.2025.1736589

1,029 views

Mini Review

Published on 07 Jan 2026

Molecular mechanisms of streptococcal disruption of the blood-brain barrier and their pathogenic role in bacterial meningitis

in Inflammation

Yumei Shi
Tao Liang
Chao Shi
Benhai Yao
Bo Xiong
Jun Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628503

831 views

Review

Published on 07 Jan 2026

Bioactives and exercise synergize to modulate AMPK and inflammation

in Inflammation

ZhaoHui Sheng
Quan Luo
XianChu Liu
Xingjie Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1670379

1,535 views

Original Research

Published on 07 Jan 2026

Exploring the impact of age, sex and life experiences on plasma inflammatory profiles through comparative proteomics

in Inflammation

Martina Bartolucci
Olga Utyro
Anita Muraglia
Alessia Repetto
Vanessa Agostini
Monica Pizzonia
Silvia Ottaviani
Gino Tripodi
Gilberto Filaci
Ranieri Cancedda

Frontiers in Immunology

doi 10.3389/fimmu.2025.1695213

958 views

Case Report

Published on 06 Jan 2026

Case Report: Refractory hidradenitis suppurativa complicated by IgA vasculitis with nephritis: successful long-term control with surgery and bimekizumab

in Inflammation

Ayaka Yasuda
Natsuko Sasaki
Emi Hasegawa
Yu Sawada

Frontiers in Immunology

doi 10.3389/fimmu.2025.1721038

1,108 views

Original Research

Published on 06 Jan 2026

From hypereosinophilia to hypereosinophilic syndrome: real-world application of a two-tailed approach for HES diagnosis

in Inflammation

Stefania Nicola
Richard Borrelli
Irene Ridolfi
Luca Lo Sardo
Simone Negrini
Monica Fornero
Nicolò Rashidy
Federica Corradi
Iuliana Badiu
Eleonora Cerutti

Frontiers in Immunology

doi 10.3389/fimmu.2025.1735131

1,019 views

Original Research

Published on 06 Jan 2026

Fusobacterium nucleatum drives CD40-mediated dendritic cell activation and Th17/Treg imbalance to exacerbate intestinal inflammation in Crohn’s disease

in Inflammation

Mingyuan Wang
Junjian Sun
Jiang Yu
Jiayun Wang
Chenjing Xu
Jingjing Ma
Hongjie Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712971

882 views

Original Research

Published on 06 Jan 2026

Identification of immune-related genes in diagnosing hypercholesterolemia with myocardial infarction through bioinformatics analysis

in Inflammation

Weibin Wu
Zheng Peng
Yi Yu
Zhenming Lin
Junyu Zhang
Meifang Lin
Caisheng Wu
Qiang Xie

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715216

789 views

Original Research

Published on 06 Jan 2026

Deciphering immune cell interaction aberrations in necrotizing enterocolitis: the regulatory role of DHRS7

in Inflammation

Kexin Gao
Yuehua Chen
Jingjing Lu
Wenliang Ge
Qiyou Yin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1743878

1,082 views

Review

Published on 05 Jan 2026

Molecular mechanisms and therapeutic progress in atherosclerosis: bridging immune inflammation and precision medicine

in Inflammation

Yimin Han
Hongyi Xu
Xinlei Yao
Zhanzhan Li
Chuli Zhu
Xia Li
Bingqian Chen
Hualin Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1737662

1,547 views

Review

Published on 05 Jan 2026

Decoding the HIF-1-driven metabolic-inflammatory-immune axis in sepsis-associated lung injury: a comprehensive overview

in Inflammation

Shuang Zhang
Beilin Hu
Yuang Fang
Mudi Liu
Qingmei Liu
Ye Chen
Jun Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658103

1,172 views

Original Research

Published on 05 Jan 2026

Low-intensity pulsed ultrasound ameliorates partial infraorbital nerve ligation-induced trigeminal neuropathic pain through inhibiting Schwann cell Pannexin 1 channel

in Inflammation

Yao Liu
Xue Han
Weijie Zhang
Qingguo Pei
Shuyu Xu
Haicheng Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712759

1,037 views

Original Research

Published on 05 Jan 2026

The role of age-related genes in idiopathic pulmonary fibrosis and molecular docking analysis of their drug targets

in Inflammation

Wei Zhang
Tingting Xia
Qian Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697013

1,452 views

Original Research

Published on 05 Jan 2026

Clostridium butyricum extracellular vesicles remodel the transcriptional network of pyroptosis-related genes in LPS-stimulated macrophages

in Inflammation

Qingyu Zhang
Kailun He
Mohd Shafiq Aazmi
Mohd Fakharul Zaman Raja Yahya

Frontiers in Immunology

doi 10.3389/fimmu.2025.1686347

1,111 views

5,774 articles

articles

Targeted interleukin-6 (IL-6) blockade by siltuximab for cytokine release syndrome control and infection limitation in thirteen patients treated with bi-specific T-cell engagers

Exploring cell death mechanisms in liver transplantation: implications for graft survival

Lung epithelial and alveolar macrophage-like cell interactions significantly modify innate responses to bacterial endotoxin with the involvement of direct cellular contacts, TNF-α, ICAM1 and MCP-1

Macrophage polarization in acute myocardial infarction: multidimensional regulation and emerging therapeutic opportunities

Extracellular CIRP augments inflammation in acute kidney injury via NKG2D-positive macrophages

Assessing the endothelium’s role in COVID-19 severity using the HUVEC model

Inflammation–Metabolism–Fibrosis Axis: Mechanisms and Therapeutic Strategies Targeting the Chronicity of Pelvic Inflammatory Disease

Elevated circulating cell-free mitochondrial DNA in fabry disease: insights into inflammatory activation

Farrerol inhibits ferroptosis and protects against LPS-induced acute lung injury by targeting the RUNX1/SLC7A11 axis

Long-term memory in epithelia: transient IFNγ exposure drives stable repression of TFF1 in gastric epithelial cells via epigenetic changes

Functional physiological, psychological, and biochemical reactivity to socially evaluated cold pressor test in hereditary angioedema patients (FRoSEn)

Molecular mechanisms of streptococcal disruption of the blood-brain barrier and their pathogenic role in bacterial meningitis

Bioactives and exercise synergize to modulate AMPK and inflammation

Exploring the impact of age, sex and life experiences on plasma inflammatory profiles through comparative proteomics

Case Report: Refractory hidradenitis suppurativa complicated by IgA vasculitis with nephritis: successful long-term control with surgery and bimekizumab

From hypereosinophilia to hypereosinophilic syndrome: real-world application of a two-tailed approach for HES diagnosis

Fusobacterium nucleatum drives CD40-mediated dendritic cell activation and Th17/Treg imbalance to exacerbate intestinal inflammation in Crohn’s disease

Identification of immune-related genes in diagnosing hypercholesterolemia with myocardial infarction through bioinformatics analysis

Deciphering immune cell interaction aberrations in necrotizing enterocolitis: the regulatory role of DHRS7

Molecular mechanisms and therapeutic progress in atherosclerosis: bridging immune inflammation and precision medicine

Decoding the HIF-1-driven metabolic-inflammatory-immune axis in sepsis-associated lung injury: a comprehensive overview

Low-intensity pulsed ultrasound ameliorates partial infraorbital nerve ligation-induced trigeminal neuropathic pain through inhibiting Schwann cell Pannexin 1 channel

The role of age-related genes in idiopathic pulmonary fibrosis and molecular docking analysis of their drug targets

Clostridium butyricum extracellular vesicles remodel the transcriptional network of pyroptosis-related genes in LPS-stimulated macrophages