Frontiers in Immunology | Molecular Innate Immunity

Original Research

Published on 13 Feb 2026

Identification of potential biomarkers related to the Bitong mixture in osteoarthritis based on bioinformatics and network pharmacology, and exploration of the mechanism involved

in Molecular Innate Immunity

Ziwei Shen
Suming Li
Teng Li
Lining Wang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1739355

138 views

Original Research

Published on 12 Feb 2026

A Treat-to-Target approach in hereditary angioedema: expert consensus from a European committee

in Molecular Innate Immunity

Mauro Cancian
Teresa Caballero
Isabelle Boccon-Gibod
Thomas Buttgereit
Danny Cohn
Efrem Eren
Sorena Kiani-Alikhan
David Launay
Johanna Mandelin
Andrea Zanichelli

Frontiers in Immunology

doi 10.3389/fimmu.2026.1773279

407 views

Original Research

Published on 12 Feb 2026

In vitro evaluation of PEI-coated microbubble– neutrophil conjugates for ultrasound-guided cell delivery

in Molecular Innate Immunity

Hossein Razmi Bagtash
Roshni Gandhi
Ghazal Rastegar
Amine Azizi
Aparna Priyadarshani Jha
Shuai Shao
Emma Salari
Shashank R. Sirsi
Caroline N. Jones

Frontiers in Immunology

doi 10.3389/fimmu.2026.1743853

259 views

Original Research

Accepted on 11 Feb 2026

PD0325901 Alleviates Thrombin-Inhibited Osteogenic Differentiation Through an IL-1β-Activated Feedback Loop between MEK-Erk1/2 and NF-κB Signal Pathways: Insights from Bioinformatics and Experimental Verification

in Molecular Innate Immunity

Yang-Shuo Ge
Chun-Meng Huang
Jun Shen
Ting-Ting Meng
Min-Jun Zhao
Jian-Li Yin
Xin-Hui Huang
Liao-Lin Chen
Jia-Hui Luo
Yu-Qing Zhai

Frontiers in Immunology

Review

Accepted on 11 Feb 2026

HMC3: rewriting the rules of microglial plasticity

in Molecular Innate Immunity

Lucia Buccarello
Anna Privitera
Konstantinos Partsinevelos
Karolina Serwa
Giuseppe Carota
Lucia Di Pietro
Vincenzo Cardaci
Renata Mangione
Jay Sibbitts
Giuseppe Lazzarino

Frontiers in Immunology

Original Research

Published on 11 Feb 2026

Salidroside targets the Notch1/Hes5 axis to reconstruct the molecular innate immune–vascular network and correlates with repair after ischemic stroke

in Molecular Innate Immunity

Jing Zeng
Xiaohua Huang
Jingyi Zeng
Qi Huang
Wenyi Song
Youfeng Xie
Guining Liang
Qingyan Wei
Yating Lan
Donghua Zou

Frontiers in Immunology

doi 10.3389/fimmu.2026.1756559

398 views

Review

Published on 10 Feb 2026

ADAR1: a central regulator of dsRNA sensing in host-virus interactions

in Molecular Innate Immunity

Congnuan Liu
Younho Choi

Frontiers in Immunology

doi 10.3389/fimmu.2026.1756517

478 views

Original Research

Accepted on 09 Feb 2026

Integrated Multi-Omics Mapping of the Causal Landscape of Gout across the Circulating-Tissue Axis

in Molecular Innate Immunity

Meng Li
Liang Huang
Jiani Liu
Xiaohui Zheng
Kai Zhang
Yixin Chen
Xiaoling Chen
Siqi Zhang
Shanshan Cai
Li Cai

Frontiers in Immunology

Mini Review

Accepted on 09 Feb 2026

Mitochondrial-targeted therapy for osteoarthritis: Challenges and opportunities from basic research to clinical translation

in Molecular Innate Immunity

SongOu Zhang
Zhiqian Gu
Jian Ruan
Jian Zhang
Hong Chen

Frontiers in Immunology

Review

Accepted on 09 Feb 2026

Taking its TOLL: The role of Toll-like receptor 4 in human health and disease, and its potential as a therapeutic target

in Molecular Innate Immunity

Phoebe Crammond
Priyanka Hastak
Anthony Delaney
Sarah C. Sasson

Frontiers in Immunology

Systematic Review

Accepted on 06 Feb 2026

Complement Response to Burn Injury: Systematic Review and Meta-Analysis of Patient and Animal Studies

in Molecular Innate Immunity

Patrick P.G. Mulder
Marit van Hooren
Roland V. Bumbuc
Carlijn R. Hooijmans
H. Ibrahim Korkmaz
Bouke Boekema

Frontiers in Immunology

148 views

Original Research

Accepted on 06 Feb 2026

Intravenous immunoglobulin remodels innate immune cell communication and induces differential autophagy pathways in Kawasaki disease

in Molecular Innate Immunity

SURAJ SINGH
Sruthi VIJAYA RETNAKUMAR
MRINMOY DAS
Srini V Kaveri
Mano Joseph Mathew
Jagadeesh BAYRY

Frontiers in Immunology

141 views

General Commentary

Published on 06 Feb 2026

Commentary: Immuno-inflammatory signature for predicting therapeutic response and survival after stereotactic radiosurgery in NSCLC patients with brain metastases: a retrospective cohort study

in Molecular Innate Immunity

Kunpeng Yang
Wenjuan Sun
Bao Wang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1782399

228 views

Editorial

Published on 06 Feb 2026

Editorial: Community series in innate immunity: platelets and their interaction with other cellular elements in host defense and disease pathogenesis, volume II

in Molecular Innate Immunity

Meganathan Kannan
Firdos Ahmad
Esaki M. Shankar

Frontiers in Immunology

doi 10.3389/fimmu.2026.1776088

690 views

Review

Published on 05 Feb 2026

Role of trained immunity in DCs and macrophages in the induction of Th2 responses and allergy treatment. What do we know?

in Molecular Innate Immunity

Hannah Ruth Schiller
Carola Zeigermann
Stefan Schülke

Frontiers in Immunology

doi 10.3389/fimmu.2026.1748337

325 views

Mini Review

Published on 05 Feb 2026

Microglia heterogeneity and therapeutic strategies in Parkinson’s disease

in Molecular Innate Immunity

Jing Tian
Xuehui Liu
Zhuoqun Wang
Xue Shi
Chunlei Dai
Li Yang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1739341

282 views

Review

Published on 04 Feb 2026

Reappraising heme oxygenase-1 as a ferroptosis modulator in atherosclerosis: a mechanism-focused review

in Molecular Innate Immunity

Jia Xu
Che Chen
Han-Ying Yuan
You-Yu Zhang
Chang-Rong Wang
Xuan Xi
Heng Pan
De-Hong Li
Yan Lu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1737751

235 views

Original Research

Published on 04 Feb 2026

Expression of Properdin, the positive regulator of the Complement Alternative Pathway, at the fetal-maternal interface in Preeclampsia

in Molecular Innate Immunity

Hadida Yasmin
Tamali Roy
Chiara Agostinis
Aishwarya Rao
Priyanka Sharma
Miriam Toffoli
Andrea Balduit
Silvia Pegoraro
Samik Bindu
Rajib Prasad

Frontiers in Immunology

doi 10.3389/fimmu.2025.1739327

685 views

Mini Review

Published on 03 Feb 2026

The pro-fibrogenic role of SPP1+ macrophages in medical implant fibrosis: mechanisms and therapeutic opportunities

in Molecular Innate Immunity

Mei Yu
Jiayin Fu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1749098

675 views

Original Research

Published on 03 Feb 2026

Differential expression of complement Properdin and Factor H in the placentae and umbilical cords of mothers with Preeclampsia, Gestational Diabetes Mellitus and Recurrent Pregnancy Loss

in Molecular Innate Immunity

Tamali Roy
Ananya Das
Nabanita Chatterjee
Shyama Prasad Saha
Rajib Prasad
Taruna Madan
Hadida Yasmin
Uday Kishore

Frontiers in Immunology

doi 10.3389/fimmu.2025.1731251

816 views

Original Research

Published on 02 Feb 2026

Neuroinflammatory and transcriptional dynamics during SARS-CoV-2 infection in KRT18-hACE2 mouse brain

in Molecular Innate Immunity

Dae-Gyun Ahn
Nhu Thi Quynh Mai
Da-Jin Jeong
Byoung-San Moon

Frontiers in Immunology

doi 10.3389/fimmu.2026.1716597

623 views

Review

Accepted on 31 Jan 2026

Sex Differences in Immune Cells: Mechanistic Perspectives and Clinical Correlates in Physiology and Disease

in Molecular Innate Immunity

Ximing Liao
Di Wu
Jing Gao
Fengyang Xie
Zhaoqi Li
Wang Muyun
Kun Wang
Yixuan Gao
Qiang Li
Wei Gao

Frontiers in Immunology

182 views

Review

Accepted on 30 Jan 2026

Beyond a Gatekeeper: The Non-Classical Signaling Role of STRA6 in Driving Endothelial Senescence and Atherosclerosis

in Molecular Innate Immunity

Yong Yuan
Jia Wang
Yunfang Zhang
Yan Yu
Weicheng Shi
Sulian Chen
Ye Kuang
Lei Feng

Frontiers in Immunology

Original Research

Accepted on 30 Jan 2026

Identification of MTURN as a Trained Immunity-Related Biomarker for Heart Failure via Integrative Transcriptomic Machine Learning Analysis and Experimental Validation

in Molecular Innate Immunity

Tianyuan Yang
Zhixin Li
Mingliang Pan
Xiaohong Wang
Wei Huang
Nebahat Ece Kesten
Tianqing Peng
Guo-Chang Fan

Frontiers in Immunology

3,596 articles

articles

Identification of potential biomarkers related to the Bitong mixture in osteoarthritis based on bioinformatics and network pharmacology, and exploration of the mechanism involved

A Treat-to-Target approach in hereditary angioedema: expert consensus from a European committee

In vitro evaluation of PEI-coated microbubble– neutrophil conjugates for ultrasound-guided cell delivery

PD0325901 Alleviates Thrombin-Inhibited Osteogenic Differentiation Through an IL-1β-Activated Feedback Loop between MEK-Erk1/2 and NF-κB Signal Pathways: Insights from Bioinformatics and Experimental Verification

HMC3: rewriting the rules of microglial plasticity

Salidroside targets the Notch1/Hes5 axis to reconstruct the molecular innate immune–vascular network and correlates with repair after ischemic stroke

ADAR1: a central regulator of dsRNA sensing in host-virus interactions

Integrated Multi-Omics Mapping of the Causal Landscape of Gout across the Circulating-Tissue Axis

Mitochondrial-targeted therapy for osteoarthritis: Challenges and opportunities from basic research to clinical translation

Taking its TOLL: The role of Toll-like receptor 4 in human health and disease, and its potential as a therapeutic target

Complement Response to Burn Injury: Systematic Review and Meta-Analysis of Patient and Animal Studies

Intravenous immunoglobulin remodels innate immune cell communication and induces differential autophagy pathways in Kawasaki disease

Commentary: Immuno-inflammatory signature for predicting therapeutic response and survival after stereotactic radiosurgery in NSCLC patients with brain metastases: a retrospective cohort study

Editorial: Community series in innate immunity: platelets and their interaction with other cellular elements in host defense and disease pathogenesis, volume II

Role of trained immunity in DCs and macrophages in the induction of Th2 responses and allergy treatment. What do we know?

Microglia heterogeneity and therapeutic strategies in Parkinson’s disease

Reappraising heme oxygenase-1 as a ferroptosis modulator in atherosclerosis: a mechanism-focused review

Expression of Properdin, the positive regulator of the Complement Alternative Pathway, at the fetal-maternal interface in Preeclampsia

The pro-fibrogenic role of SPP1+ macrophages in medical implant fibrosis: mechanisms and therapeutic opportunities

Differential expression of complement Properdin and Factor H in the placentae and umbilical cords of mothers with Preeclampsia, Gestational Diabetes Mellitus and Recurrent Pregnancy Loss

Neuroinflammatory and transcriptional dynamics during SARS-CoV-2 infection in KRT18-hACE2 mouse brain

Sex Differences in Immune Cells: Mechanistic Perspectives and Clinical Correlates in Physiology and Disease

Beyond a Gatekeeper: The Non-Classical Signaling Role of STRA6 in Driving Endothelial Senescence and Atherosclerosis

Identification of MTURN as a Trained Immunity-Related Biomarker for Heart Failure via Integrative Transcriptomic Machine Learning Analysis and Experimental Validation