Frontiers in Immunology | Molecular Innate Immunity

Original Research

Published on 24 Nov 2025

Circulating innate lymphoid cells and IL-18 as potential immune biomarkers in thymic tumors

in Molecular Innate Immunity

Daniela Claudia Maresca
Maria Rosaria Saponaro
Evelina La Civita
Marianna Tortora
Benedetta Romano
Erica Pietroluongo
Fabio Somma
Mario Giuliano
Alberto Servetto
Giovannella Palmieri

Frontiers in Immunology

doi 10.3389/fimmu.2025.1705648

882 views

Original Research

Published on 21 Nov 2025

Phosphorylation-driven effector switching of Rab7 and Rab12 by the leucine-rich repeat kinase 1 in mast cells

in Molecular Innate Immunity

Jana Omar-Kabha
Sewar Omari
Yaara Gorzalczany
Fatima Amer-Sarsour
Elisabeth Kleeblatt
Mitsunori Fukuda
Avraham Ashkenazi
Ronit Sagi-Eisenberg

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709196

727 views

General Commentary

Published on 20 Nov 2025

Commentary: Complement genetic variants and FH desialylation in S. pneumoniae-haemolytic uraemic syndrome

in Molecular Innate Immunity

Laura M. Baas
Nicole C. A. J. van de Kar
Marloes A. H. M. Michels
Lambertus P. van den Heuvel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707529

682 views

Original Research

Published on 19 Nov 2025

Manganese mediates antiviral effects by driving an ATM -TBK1 phosphorylation signaling pathway

in Molecular Innate Immunity

Hongyan Sui
Rosana Wiscovitch-Russo
Silvia Cachaco
Jun Yang
Whitney Bruchey
Sylvain Laverdure
Qian Chen
Tomozumi Imamichi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708516

868 views

Original Research

Published on 19 Nov 2025

Plasma lipidomic signatures reveal age-associated patterns of septic shock risk and immune dysregulation in sepsis

in Molecular Innate Immunity

Yuhan Sun
Ke Lin
Ling Wang
Jingwen Ai
Jingjing Zhao
Ruiwen Sun
Xiaoyang Cheng
Yanmin Wan
Peng Cui
Sen Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1659425

1,160 views

Original Research

Published on 19 Nov 2025

Significant alterations in peripheral lymphocyte subsets and immune-related protein profiles in patients with periprosthetic joint infection

in Molecular Innate Immunity

Zhuo Li
Fan Yang
Jun Fu
Zhi-Yuan Li
Li-Bo Hao
Lin Yuan
Ji-Ying Chen
Chi Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1648150

625 views

Original Research

Published on 18 Nov 2025

RIG-I drives protective type I interferon production by glial cells in response to Neisseria meningitidis and Streptococcus pneumoniae challenge

in Molecular Innate Immunity

Krishna J. Majithia
M. Brittany Johnson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692421

1,142 views

Original Research

Accepted on 17 Nov 2025

Accumulation of free nuclei denotes defective phagocytic capacity of macrophages and occurs after infection with Listeria monocytogenes and Lymphocytic Choriomeningitis Virus (LCMV)

in Molecular Innate Immunity

Theresa Charlotte Christ
Justa Friebus-Kardash
Michael Bergerhausen
Abdelrahman Elwy
Hossam Abdelrahman
Lisa Holnsteiner
Elisa Wiebeck
Ilka Geuer
Alexander Gerbaulet
Philipp A Lang

Frontiers in Immunology

114 views

Original Research

Published on 17 Nov 2025

Comprehensive analysis of metabolism-related genes in sepsis reveals metabolic–immune heterogeneity and highlights GYG1 as a potential therapeutic target

in Molecular Innate Immunity

Jie Zheng
Kangjie Qin
Xiaoqin Wang
Banghai Feng
Yuting Zhang
Yiyu Wang
Han Qin
Qiuyu Dai
Xinxin Liu
Kun Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682846

1,227 views

Original Research

Published on 17 Nov 2025

Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target

in Molecular Innate Immunity

Fan Lu
Houkang Lei
Xiang Xiao
Luzhu Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1700781

1,357 views

Original Research

Published on 14 Nov 2025

Extracellular microRNAs modulate human microglial function through TLR8

in Molecular Innate Immunity

Hannah Weidling
Edyta Motta
Leonard D. Kuhrt
Christina Krüger
Caio Andreeta Figueiredo
Thomas Wallach
Silke Frahm
Sebastian Diecke
Susanne A. Wolf
Helmut Kettenmann

Frontiers in Immunology

doi 10.3389/fimmu.2025.1645062

1,722 views

Original Research

Published on 13 Nov 2025

Cold temperature enhances innate eosinophilic airway inflammation via transient receptor potential ankyrin1

in Molecular Innate Immunity

Yoichi Dotake
Takahiro Matsuyama
Kentaro Machida
Hiromi Matsuyama
Koichi Takagi
Keiko Mizuno
Keiko Kan-o
Tomoyuki Kuwaki
Hiromasa Inoue
Kentaro Tanaka

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655919

1,449 views

Review

Published on 13 Nov 2025

Circular RNAs and their emerging roles in muscular immune-related diseases

in Molecular Innate Immunity

Felicita Urzi
Anja Srpčič
Katja Lakota

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675567

1,451 views

Editorial

Published on 10 Nov 2025

Editorial: Oral immunology – interplay of molecules, cells and oral tissue environment

in Molecular Innate Immunity

James Deschner
Kerstin Galler
Jonathan Jantsch

Frontiers in Immunology

doi 10.3389/fimmu.2025.1729801

520 views

Original Research

Published on 04 Nov 2025

Deciphering oligomeric proanthocyanidins’ dual osteoprotective mechanisms at single-cell resolution: NR4A1-mediated PTGS2 suppression and β-catenin-Runx2 activation

in Molecular Innate Immunity

Li Huang
Yuwei Sun
Yi Zheng
Shicheng Qiu
Jianping Zheng
Chunhan Sun
Mingwei Chen
Shaowei Zheng
Yirong Zeng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679987

1,379 views

Mini Review

Published on 04 Nov 2025

From chronic inflammation to immune escape: mapping the tumor microenvironment evolution in renal cell carcinoma

in Molecular Innate Immunity

Hanjun Xu
Baojun Tu
Hui Li
Yong Shan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1683844

1,391 views

Review

Published on 03 Nov 2025

Regulation of the innate immune response in rheumatoid arthritis

in Molecular Innate Immunity

Aikeremujiang Muheremu
Shalayiding Aierxiding
Jian Gao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1545625

1,684 views

Mini Review

Published on 03 Nov 2025

Immune snapshots along the inflammation-to-cancer road in bladder urothelium

in Molecular Innate Immunity

Lingxiang Lu
Fei Wang
Zhenfan Wang
Shuai Guo
Minjun Jiang
Zheng Ma

Frontiers in Immunology

doi 10.3389/fimmu.2025.1685237

1,209 views

Mini Review

Published on 31 Oct 2025

The complement pathway and the pathophysiology of fibroproliferative cutaneous scarring

in Molecular Innate Immunity

Ilja L. Kruglikov
Katarzyna Walendzik
Philipp E. Scherer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701998

1,159 views

Original Research

Published on 31 Oct 2025

Global research hotspots and trends in microglia in ischemic stroke

in Molecular Innate Immunity

Yingquan Liu
Yu Ye
Fan Dai
Lin Bai
Hongjie Ji
Xingxing Su
Peijia Hu
Hongliang Cheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1622499

1,329 views

Original Research

Published on 31 Oct 2025

Single-cell and spatial transcriptomics integration reveals FAM49B promotes tumor-associated macrophages polarization in colorectal cancer via the MK pathway

in Molecular Innate Immunity

Tianyu Liu
Quchen Ding
Jin Gou
Chen Lu
Xingming Lu
Jiatong Chen
Yiming E.
Lianhong Li
Chongguo Zhang
Xiaojuan Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682637

2,666 views

Original Research

Published on 30 Oct 2025

Lactylation-related gene AKR1A1 contributes to osteoporosis via metabolic–immune regulation: evidence from multi-omics integration, single-cell transcriptomics, and in vitro validation

in Molecular Innate Immunity

Zichen Shao
Qinqin Deng
Ling Cheng
Jianfeng Wu
Weikang Sun
Weidong Liang
Huanan Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680305

1,997 views

Original Research

Published on 30 Oct 2025

Deficiency of HMGN2 enhances antibacterial activity of macrophages by promoting H3 histone modification-mediated CD14/iNOS expression

in Molecular Innate Immunity

Zhen Yang
Xiao Zhang
Chaoqun Liu
Ning Huang
Yan Teng
Junming Miao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621440

1,207 views

Original Research

Published on 29 Oct 2025

Necrosis by sodium overload-associated genes TRPM4 and SLC9A1: biological roles and clinical implications in breast cancer progression

in Molecular Innate Immunity

Yingze Zhu
Yaxin Guo
Yanlin Su
Zhuoqi Zhang
Yige Lu
Xianghan Zhang
Hui Pang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1623511

1,506 views

3,544 articles

articles

Circulating innate lymphoid cells and IL-18 as potential immune biomarkers in thymic tumors

Phosphorylation-driven effector switching of Rab7 and Rab12 by the leucine-rich repeat kinase 1 in mast cells

Commentary: Complement genetic variants and FH desialylation in S. pneumoniae-haemolytic uraemic syndrome

Manganese mediates antiviral effects by driving an ATM -TBK1 phosphorylation signaling pathway

Plasma lipidomic signatures reveal age-associated patterns of septic shock risk and immune dysregulation in sepsis

Significant alterations in peripheral lymphocyte subsets and immune-related protein profiles in patients with periprosthetic joint infection

RIG-I drives protective type I interferon production by glial cells in response to Neisseria meningitidis and Streptococcus pneumoniae challenge

Accumulation of free nuclei denotes defective phagocytic capacity of macrophages and occurs after infection with Listeria monocytogenes and Lymphocytic Choriomeningitis Virus (LCMV)

Comprehensive analysis of metabolism-related genes in sepsis reveals metabolic–immune heterogeneity and highlights GYG1 as a potential therapeutic target

Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target

Extracellular microRNAs modulate human microglial function through TLR8

Cold temperature enhances innate eosinophilic airway inflammation via transient receptor potential ankyrin1

Circular RNAs and their emerging roles in muscular immune-related diseases

Editorial: Oral immunology – interplay of molecules, cells and oral tissue environment

Deciphering oligomeric proanthocyanidins’ dual osteoprotective mechanisms at single-cell resolution: NR4A1-mediated PTGS2 suppression and β-catenin-Runx2 activation

From chronic inflammation to immune escape: mapping the tumor microenvironment evolution in renal cell carcinoma

Regulation of the innate immune response in rheumatoid arthritis

Immune snapshots along the inflammation-to-cancer road in bladder urothelium

The complement pathway and the pathophysiology of fibroproliferative cutaneous scarring

Global research hotspots and trends in microglia in ischemic stroke

Single-cell and spatial transcriptomics integration reveals FAM49B promotes tumor-associated macrophages polarization in colorectal cancer via the MK pathway

Lactylation-related gene AKR1A1 contributes to osteoporosis via metabolic–immune regulation: evidence from multi-omics integration, single-cell transcriptomics, and in vitro validation

Deficiency of HMGN2 enhances antibacterial activity of macrophages by promoting H3 histone modification-mediated CD14/iNOS expression

Necrosis by sodium overload-associated genes TRPM4 and SLC9A1: biological roles and clinical implications in breast cancer progression