Frontiers in Immunology | Molecular Innate Immunity

Original Research

Published on 14 Jan 2026

PKCϵ-mediated phosphorylation of TRPC3 channel at S712 is essential for its inactivation during inflammatory signaling

in Molecular Innate Immunity

Javier Casas
Clara Meana
Gonzalo San-José
Jesús Balsinde
María A. Balboa

Frontiers in Immunology

doi 10.3389/fimmu.2025.1737430

1,047 views

Review

Published on 13 Jan 2026

Mitochondrial DAMPs as a critical driver in the development of acute graft versus host disease and emerging mitochondria targeted therapeutic strategies

in Molecular Innate Immunity

Vasantharaja Raguraman
Yogamaya Divakar Prabhu
Gopal Viswanathan Velmurugan
Gerhard C. Hildebrandt
Senthilnathan Palaniyandi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1740433

1,218 views

Review

Published on 13 Jan 2026

Bitter taste receptors in the gut-vascular axis: a novel target for immune and metabolic regulation of hypertension

in Molecular Innate Immunity

Xiaoyu Wei
Feifei Lyu
Fuyun Jia
Lihong Zhang
Min Zhang
Qiang Xu
Shengyu Hua

Frontiers in Immunology

doi 10.3389/fimmu.2025.1714761

962 views

Editorial

Published on 13 Jan 2026

Editorial: IUIS junior community: pushing the frontiers of immunology

in Molecular Innate Immunity

Adeleye O. Adeshakin
Anne M. Hahn

Frontiers in Immunology

doi 10.3389/fimmu.2025.1768685

524 views

Original Research

Accepted on 12 Jan 2026

SLC31A1 knockdown mitigates post-MI heart failure via regulation of copper metabolism

in Molecular Innate Immunity

Qi Wei
Ling Qin
Jie Sun
Huanyu Zhou

Frontiers in Immunology

125 views

Review

Published on 12 Jan 2026

Role and mechanism of gut microbiota in regulating interferon-mediated programmed cell death in colorectal cancer

in Molecular Innate Immunity

Qipeng Yao
Shiyin Chen
Weiwei Qian
Chao Yang
Junxian Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1724908

1,115 views

Mini Review

Published on 12 Jan 2026

Research progress on protein tyrosine phosphatase A from Mycobacterium tuberculosis

in Molecular Innate Immunity

Yifei Cai
Leiliang Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1754992

693 views

Original Research

Published on 12 Jan 2026

Catalogue of LPS-induced transcriptional changes across vertebrates identifies syntenically conserved human long non-coding RNAs that regulate the innate immune response

in Molecular Innate Immunity

Marina R. Hadjicharalambous
Richard R. Ryder
Peter S. Fenwick
Louise E. Donnelly
Mark A. Lindsay

Frontiers in Immunology

doi 10.3389/fimmu.2025.1686490

773 views

Original Research

Published on 12 Jan 2026

Lipid and immune dysregulation and risk of metabolic disorders after HCV clearance in HIV/HCV-coinfected participants with cACLD: a retrospective study

in Molecular Innate Immunity

Ana Virseda-Berdices
Belen Requena
Juan Berenguer
Juan González-García
Carolina Gonzalez-Riano
Cristina Díez
Victor Hontañon
Amanda Fernández-Rodríguez
Coral Barbas
Salvador Resino

Frontiers in Immunology

doi 10.3389/fimmu.2025.1674837

686 views

Original Research

Published on 09 Jan 2026

Sustained STING-IRF7 signaling aggravates LPS-induced endometrial inflammation via excessive neutrophil extracellular traps generation

in Molecular Innate Immunity

Min Chu
Ding Ma
Zhan Song
Li Liang
Fengjuan Xing
Hongchu Bao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671848

1,019 views

Review

Published on 09 Jan 2026

PRMT3 at the crossroads of inflammation: dual roles in metabolic reprogramming and immune dysregulation in chronic diseases

in Molecular Innate Immunity

Huining Hou
Jiaojiao Meng
Yingqing Chen
Xili Zhang
Zhuqing Yang
Qianqian Wang
Min Zheng
Zebo Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663258

1,021 views

Original Research

Published on 08 Jan 2026

Modulation of IRAK4 as a therapeutic strategy against monosodium urate- and xanthine-induced inflammation in macrophages and HepG2 cells

in Molecular Innate Immunity

Sadiq Umar
Huan T. Chang
Mark Maienschein-Cline
Sriram Ravindran

Frontiers in Immunology

doi 10.3389/fimmu.2025.1744393

1,104 views

Original Research

Published on 07 Jan 2026

Pre‑partum blood leukocyte profiles distinguish gestational inflammatory stages that predict birth‑related adverse outcomes

in Molecular Innate Immunity

Hari Shankar
Yash Gupta
Neeta Kumar
William M. Trochim
Almira L. Hoogesteijn
Jeanne M. Fair
Raja Babu Singh Kushwah
Michelle J. Iandiorio
Donthamsetty Nageswara Rao
Ariel L. Rivas

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677992

1,014 views

Review

Published on 07 Jan 2026

Ferroptosis-immune-metabolic axis in asthma: mechanistic crosstalk, endotype-specific regulation, and translational targeting

in Molecular Innate Immunity

Feng-Xian Ni
Jie Hu
Pei-Sheng Chen
Hui-Hui Chen
Dong-Hui Huang
Ze-Bo Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1714608

1,448 views

Original Research

Published on 06 Jan 2026

Dual role of ACE2 in regulating inflammation triggered by Omicron S1 and other SARS-CoV-2 Spike variants

in Molecular Innate Immunity

Annamaria Pedoto
Juan M. Lozano-Gil
María Ocaña-Esparza
Ana M. Conesa-Hernández
Sergio Candel
María L. Cayuela
Victoriano Mulero
Sylwia D. Tyrkalska

Frontiers in Immunology

doi 10.3389/fimmu.2025.1667880

1,035 views

Original Research

Published on 05 Jan 2026

Regnase-1 in cDC1 controls T cell priming and shapes the dynamics of experimental autoimmune encephalomyelitis

in Molecular Innate Immunity

Xingyu Rong
Hai Wang
Shintaro Muraoka
Takuya Uehata
Masanori Yoshinaga
Tsuneyasu Kaisho
Osamu Takeuchi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1725702

1,490 views

Original Research

Published on 05 Jan 2026

Cbl promotes MyD88 ubiquitin-mediated degradation in macrophages via phosphorylation and calcium mobilization

in Molecular Innate Immunity

Yan Zhang
Dan Wang
Jie Huang
Zhefan Wang
Jinren Zhu
Feihan Lyu
Zhengyu Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679035

639 views

Review

Published on 05 Jan 2026

The multifaceted role of post-translational modifications in macrophage polarization: from mechanisms to therapeutic targets

in Molecular Innate Immunity

Rui Guo
Feng Qi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1749857

1,212 views

Original Research

Published on 05 Jan 2026

Melanoma causes phenotypic modulations and metabolic switches of iNKT cells influencing clinical outcomes

in Molecular Innate Immunity

Emmanuelle Degeorges
Stéphane Mouret
Pauline Girard
Camille Niveau
Mélanie Cettour-Cave
Eleonora Sosa Cuevas
Florence De Fraipont
Julie Charles
Philippe Saas
Caroline Aspord

Frontiers in Immunology

doi 10.3389/fimmu.2025.1703754

900 views

Original Research

Published on 05 Jan 2026

TGFβ1 attenuates microglial IL1β release through inhibition of NLRP3 inflammasome priming

in Molecular Innate Immunity

Christopher Kalischer
Phani Sankar Potru
Nele Lehmann
Jannik Jahn
Nikolai Leander Rupp
Natascha Vidovic
Tamara Russ
Susanne Wiemann
Björn Spittau

Frontiers in Immunology

doi 10.3389/fimmu.2025.1623643

1,082 views

Editorial

Published on 05 Jan 2026

Editorial: Sentinels of the immune system: tissue-resident macrophages in the battle against infection and autoimmunity

in Molecular Innate Immunity

Lalit Batra
Shilpi Giri
Shailesh K. Shahi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1759310

553 views

Correction

Published on 02 Jan 2026

Correction: Manganese mediates antiviral effects by driving an ATM-TBK1 phosphorylation signaling pathway

in Molecular Innate Immunity

Hongyan Sui
Rosana Wiscovitch-Russo
Silvia Cachaco
Jun Yang
Whitney Bruchey
Sylvain Laverdure
Qian Chen
Tomozumi Imamichi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1770238

907 views

Case Report

Published on 02 Jan 2026

Case Report: Possible C3 nephritic factor–driven complement-mediated severe hemolytic anemia and acute kidney injury in a child with Bordetella parapertussis infection

in Molecular Innate Immunity

Steffen Ullitz Thorsen
Anne Todsen Hansen
Hans Jakob Hartling
Hanne Vibeke Marquart
Line Borgwardt
Mira Marie Laustsen
Lillemor Skattum
Alex Christian Yde Nielsen
Line Thousig Sehested
Hanne Nørgaard

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715464

1,583 views

Original Research

Published on 02 Jan 2026

The role of gasdermin-mediated mitochondrial RNA release in amplifying secondary immune response during microbial infection

in Molecular Innate Immunity

Uzair Afaq
Muhammad Suhaib Qudus
Siyu Liu
Kailang Wu
Yu Chen
Mingfu Tian
Jianguo Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1668763

1,300 views

3,596 articles

articles

PKCϵ-mediated phosphorylation of TRPC3 channel at S712 is essential for its inactivation during inflammatory signaling

Mitochondrial DAMPs as a critical driver in the development of acute graft versus host disease and emerging mitochondria targeted therapeutic strategies

Bitter taste receptors in the gut-vascular axis: a novel target for immune and metabolic regulation of hypertension

Editorial: IUIS junior community: pushing the frontiers of immunology

SLC31A1 knockdown mitigates post-MI heart failure via regulation of copper metabolism

Role and mechanism of gut microbiota in regulating interferon-mediated programmed cell death in colorectal cancer

Research progress on protein tyrosine phosphatase A from Mycobacterium tuberculosis

Catalogue of LPS-induced transcriptional changes across vertebrates identifies syntenically conserved human long non-coding RNAs that regulate the innate immune response

Lipid and immune dysregulation and risk of metabolic disorders after HCV clearance in HIV/HCV-coinfected participants with cACLD: a retrospective study

Sustained STING-IRF7 signaling aggravates LPS-induced endometrial inflammation via excessive neutrophil extracellular traps generation

PRMT3 at the crossroads of inflammation: dual roles in metabolic reprogramming and immune dysregulation in chronic diseases

Modulation of IRAK4 as a therapeutic strategy against monosodium urate- and xanthine-induced inflammation in macrophages and HepG2 cells

Pre‑partum blood leukocyte profiles distinguish gestational inflammatory stages that predict birth‑related adverse outcomes

Ferroptosis-immune-metabolic axis in asthma: mechanistic crosstalk, endotype-specific regulation, and translational targeting

Dual role of ACE2 in regulating inflammation triggered by Omicron S1 and other SARS-CoV-2 Spike variants

Regnase-1 in cDC1 controls T cell priming and shapes the dynamics of experimental autoimmune encephalomyelitis

Cbl promotes MyD88 ubiquitin-mediated degradation in macrophages via phosphorylation and calcium mobilization

The multifaceted role of post-translational modifications in macrophage polarization: from mechanisms to therapeutic targets

Melanoma causes phenotypic modulations and metabolic switches of iNKT cells influencing clinical outcomes

TGFβ1 attenuates microglial IL1β release through inhibition of NLRP3 inflammasome priming

Editorial: Sentinels of the immune system: tissue-resident macrophages in the battle against infection and autoimmunity

Correction: Manganese mediates antiviral effects by driving an ATM-TBK1 phosphorylation signaling pathway

Case Report: Possible C3 nephritic factor–driven complement-mediated severe hemolytic anemia and acute kidney injury in a child with Bordetella parapertussis infection

The role of gasdermin-mediated mitochondrial RNA release in amplifying secondary immune response during microbial infection